{"product_id":"abcam-ab317391","title":"Abcam, ab317391, Anti-MMP26 antibody [S01-7A4]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Monoclonal MMP26 antibody. Suitable for WB and reacts with Human, Rat, Chinese hamster samples. Immunogen corresponding to Synthetic Peptide within Human MMP26.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:S01-7A4,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Rat, Chinese hamster,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human MMP26.Q9NRE1\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.01% Sodium azideConstituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMMP26 also known as matrix metalloproteinase-26 or endometase is an enzyme that degrades components of the extracellular matrix. This metalloproteinase part of the larger MMP family has a mass of approximately 28 kDa. MMP26 expresses in various tissues notably in the uterus and specific cancerous cells. The enzyme's primary function involves breaking down proteins such as collagen and gelatin contributing to tissue remodeling and repair processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMMP26 plays a critical role in cellular responses that require remodeling of the extracellular matrix. It is part of the metalloproteinase family which function as zinc-dependent endopeptidases. MMP26 often forms complexes with tissue inhibitors of metalloproteinases (TIMPs) which regulate its activity. This regulatory mechanism is vital in maintaining a balance between matrix degradation and deposition important for normal physiological processes like wound healing and embryogenesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nMMP26 associates intricately with extracellular matrix degradation and tissue remodeling pathways. One important pathway includes the regulation of the extracellular matrix organization. The enzyme interacts closely with other matrix metalloproteinases such as MMP9 and MMP2 which also play roles in similar pathways contributing to various biological processes like cell migration and angiogenesis.\u003cbr\u003e\nMMP26 shows a notable connection to cancer progression and metastasis. The enzymatic activity of MMP26 enables cancerous cells to invade surrounding tissues by degrading the extracellular matrix. This characteristic links the enzyme to breast cancer where it often shows overexpression. MMP26 also associates with other metalloproteinases like MMP9 in the tumor microenvironment influencing tumor growth and invasion.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850363654313,"sku":"ab317391","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab317391","provider":"Iright","version":"1.0","type":"link"}