{"product_id":"abcam-ab318205","title":"Abcam, ab318205, Anti-TCR beta antibody [RM2056]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Multiclonal T Cell Receptor antibody. Suitable for WB, IHC-P, mIHC and reacts with Transfected cell lysate - Human, Transfected cell lysate - Mouse, Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Multiclonal,\u003cbr\u003e\nClone number:RM2056,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:IHC-P, WB, mIHCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are recombinant multiclonals?\u003cbr\u003e\nRecombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:\u003cbr\u003e\n- The sensitivity of polyclonal antibodies by recognising multiple epitopes\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nView our range of\u003cbr\u003e\nrecombinant multiclonal antibodies\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTCR beta also known as T-cell receptor beta is an integral component of the T-cell receptor (TCR) complex. It weighs approximately 40-50 kDa and is expressed on the surface of T cells. TCR beta contributes to the recognition of antigens by interacting with peptide fragments presented by major histocompatibility complex (MHC) molecules. This interaction is essential for T-cell activation which plays a significant role in the adaptive immune response.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTCR beta is part of the T-cell receptor complex. This complex is critical for antigen recognition and T-cell signaling. The complex comprises multiple subunits including CD3 chains that facilitate signal transduction upon antigen binding. This initiates a cascade of intracellular events leading to T-cell activation and proliferation. TCR beta's role in this complex makes it essential for recognizing pathogens and initiating immune responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nTCR beta is involved in T-cell receptor signaling and adaptive immune pathways. It is closely associated with the Zap70 protein which transmits activation signals from the TCR upon antigen recognition. This signaling cascade further activates the MAPK and NF-κB pathways influencing T-cell differentiation and cytokine production. The interaction between TCR beta and these pathways highlights its fundamental role in immune system regulation.\u003cbr\u003e\nDysregulation of TCR beta can contribute to autoimmune diseases and certain types of cancer. For instance aberrant TCR signaling can lead to autoimmunity where T cells attack the body's own tissues. Additionally in some leukemias mutations or rearrangements involving the TCR beta chain can promote uncontrolled cell proliferation. TCR beta's involvement with HLA proteins in autoimmune conditions showcases its significance in disease development and management.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844220244137,"sku":"ab318205","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab318205","provider":"Iright","version":"1.0","type":"link"}