{"product_id":"abcam-ab318942","title":"Abcam, ab318942, Recombinant Dengue Virus 4 NS1 glycoprotein","description":"\u003cp\u003eSize: 10µg \/ 50µg \/ 100µg\u003cbr\u003e\nRecombinant Dengue Virus 4 NS1 glycoprotein is a Dengue virus 4 Dominica\/814669\/1981 Full Length protein, expressed in HEK 293 cells, with \u0026gt;95%, 0.005 EU\/µg endotoxin level, suitable for Mass Spec, HPLC, SDS-PAGE.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95% HPLC,\u003cbr\u003e\nEndotoxin level:0.005 EU\/µg,\u003cbr\u003e\nExpression system:HEK 293 cells,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:Mass Spec, SDS-PAGE, HPLCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nMass Spectrometry:LC-MS\/MS,\u003cbr\u003e\nAccession:P09866,\u003cbr\u003e\nAnimal free:Yes,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Dengue virus 4 Dominica\/814669\/1981,\u003cbr\u003e\nStorage buffer:pH: 7.4Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Dengue Virus 4 NS1 glycoprotein also known as non-structural protein 1 plays an important role in the viral replication and immune evasion mechanisms of the Dengue virus. Weighing approximately 46-55 kDa NS1 exists both as a monomer and a dimer displaying versatility in its function. It is expressed in infected host cells and can be secreted into the bloodstream or be present in cellular membranes. This flexibility allows it to interact directly with various elements of the host cell system contributing to its pathogenicity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNS1 glycoprotein in Dengue Virus 4 is integral to viral replication and immune modulation. It does not work alone but rather functions as part of a larger complex with other viral proteins to effectively hijack host cellular machinery. NS1 is involved in the formation of replication complexes that along with its immunomodulatory activities suppress host immune responses. Importantly NS1's ability to disrupt the complement system highlights its role in immune evasion and pathogenesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nSeveral aspects of NS1 function link to host inflammatory and immune response pathways. NS1 interacts within the viral replication pathway engaging with the host's innate immune response. Proteins such as NS2B and NS3 closely relate to NS1 through these pathways functioning together to facilitate efficient virus replication and modulation of host defenses. NS1 contributes to the manipulation of the immune signaling pathways supporting the virus's resistance to host immune clearance mechanisms.\u003cbr\u003e\nThe role of NS1 glycoprotein in Dengue Virus 4 connects it to diseases such as Dengue Fever and Dengue Hemorrhagic Fever. NS1 levels in the bloodstream correlate with disease severity making it a marker for diagnosis and prognosis. Through its interaction with other viral proteins including E protein and NS3 NS1 affects host vascular permeability leading to hemorrhagic manifestations in severe disease cases. The molecular interactions highlight NS1's potential as a target for therapeutic intervention and vaccine development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843895414953,"sku":"ab318942","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab318942","provider":"Iright","version":"1.0","type":"link"}