{"product_id":"abcam-ab318978","title":"Abcam, ab318978, Anti-LDB1 antibody [EPR28912-75]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal LDB1 antibody. Suitable for Dot, IHC-P, ICC\/IF, WB, IP, Flow Cyt (Intra) and reacts with Synthetic peptide - Human, Mouse, Rat, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28912-75,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, Dot, Flow Cyt (Intra), IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Not suitable for human IHC-P.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLDB1 also known as LIM Domain Binding 1 serves an important role in transcriptional regulation. This protein with a mass of approximately 42 kDa frequently expresses in tissues such as the brain heart and spleen. LDB1 participates in forming multiprotein complexes through its interaction with LIM homeodomain proteins engaging with various co-regulators to influence gene expression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLIM Domain Binding 1 plays an important role in developmental processes and cell differentiation. It combines with other proteins to form a LIM complex that acts as a DNA-binding transcriptional regulator. The complex binds to enhancer elements and facilitates the activation or repression of genes critical for the development of the nervous system and cardiovascular system.\u003cbr\u003e\nPathways\u003cbr\u003e\nLIM Domain Binding 1 integrates into the Wnt signaling pathway and the TGF-beta pathway. It interacts with proteins such as TCF\/LEF and Smad serving as a cofactor that modulates transcriptional responses and influences cellular outcomes. By participating in these pathways LDB1 helps regulate cell fate decisions ensuring appropriate cellular differentiation and proliferation responses.\u003cbr\u003e\nLIM Domain Binding 1 holds relevance to leukemia and Wilms' tumor. Its dysregulation connects with disproportionate expression of key developmental genes contributing to pathogenesis. LDB1's interaction with transcription factors like SCL\/TAL1 highlights its contribution to the onset of these diseases by modulating gene expression patterns associated with these cancers.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850319909033,"sku":"ab318978","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab318978","provider":"Iright","version":"1.0","type":"link"}