{"product_id":"abcam-ab318981","title":"Abcam, ab318981, Anti-TIGAR antibody [EPR29002-30] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TIGAR antibody. Carrier free. Suitable for WB, ICC\/IF and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR29002-30,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab318981 is the carrier-free version of\u003cbr\u003e\nab318980\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTIGAR also known as TP53-Induced Glycolysis and Apoptosis Regulator is a protein involved in cellular metabolism. With a mass of approximately 28 kDa TIGAR regulates glycolysis by acting similarly to fructose-26-bisphosphatase. It is expressed predominantly in tissues with active cellular proliferation such as the brain and liver. TIGAR functions mechanically to inhibit the glycolytic flux by decreasing levels of fructose-26-bisphosphate which is important for various cellular activities.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTIGAR plays a critical role in controlling the oxidative stress within cells. By lowering glycolytic rates it shifts cellular metabolism toward the pentose phosphate pathway boosting the production of NADPH and reducing reactive oxygen species (ROS). This protein does not form a part of a larger complex operating independently to exhibit its effects. It also influences cellular survival mechanisms by mitigating oxidative stress which is important for cell health.\u003cbr\u003e\nPathways\u003cbr\u003e\nTIGAR is involved with both apoptosis and carbohydrate metabolism pathways where it acts to support cellular metabolism and survival. Within these pathways it interacts closely with the tumor suppressor protein p53 which regulates TIGAR expression. Another related protein is AMPK which also plays roles in energy balance and is influenced by changes in cellular metabolic status. TIGAR's actions help in cellular adaptation during metabolic stress maintaining energy homeostasis.\u003cbr\u003e\nTIGAR is linked to cancer and neurodegenerative diseases. Its role in reducing oxidative stress makes it significant in cancer as elevated levels can sometimes promote cancer cell survival. Involvement with p53 is particularly notable as alterations in p53 pathways are common in various cancers. In neurodegenerative diseases such as Alzheimer's TIGAR's function in managing oxidative stress can affect neuronal survival. Dysregulation of related metabolic processes can contribute to disease progression highlighting the importance of TIGAR in these contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851863412905,"sku":"ab318981","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab318981","provider":"Iright","version":"1.0","type":"link"}