{"product_id":"abcam-ab318982","title":"Abcam, ab318982, Anti-UNG2 antibody [EPR29004-78]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal UNG antibody. Suitable for Dot, IHC-P, WB and reacts with Synthetic peptide, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR29004-78,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Dot, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:The immunogen is located within the N-terminal region of UNG2 (P13051-1). Based on peptide dot blot data we do not expect this antibody to cross-react with UNG1 (P13051-2).\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUNG2 also known as uracil-DNA glycosylase 2 is a DNA repair enzyme with a mass of about 36 kDa. It operates mainly in the cell nucleus where it plays an important role in the base excision repair pathway. The enzyme detects and removes uracil from DNA molecules which often forms through deamination of cytosine or incorporation of dUMP instead of dTMP during DNA replication. By cleaving the N-glycosidic bond of uracil UNG2 initiates a repair process that helps maintain genetic integrity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe enzyme has a significant role in preserving the accuracy of genetic information. UNG2 works independently but it acts closely with other repair enzymes in the context of DNA damage response. UNG2 excises uracil efficiently facilitating downstream actions by other repair mechanisms which complete the repair process. The enzyme's activity ensures that DNA mutations which may compromise cellular functions or lead to diseases do not accumulate.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe enzyme participates actively in the base excision repair pathway. This pathway critical for correcting small base lesions in DNA involves several components including APE1 and DNA polymerase beta. UNG2 collaborates with these proteins to ensure successful repair. Beyond this UNG2's activity is also linked to immunoglobulin gene diversification processes necessary for adaptive immunity thereby involving itself in immunity pathways.\u003cbr\u003e\nExcessive or deficient activity of UNG2 links to certain conditions. Disruption in UNG2 function may contribute to cancer development due to its role in repairing DNA and preventing mutations. The enzyme's actions also intersect with viral infections; certain viruses such as Epstein-Barr virus may manipulate UNG2 function to favor their replication. Exploring these interactions can provide insights into potential therapeutic targets for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850460287145,"sku":"ab318982","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab318982","provider":"Iright","version":"1.0","type":"link"}