{"product_id":"abcam-ab319045","title":"Abcam, ab319045, Anti-Dynorphin A antibody [EPR28632-17]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ProDynorphin antibody. Suitable for Dot, IHC-P, ICC\/IF, IHC-Fr and reacts with Synthetic peptide - Mouse, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28632-17,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:Dot, ICC\/IF, IHC-Fr, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This clone works only in the hippocampus of mouse and rat. Unsuitable for rat ICC.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDynorphin A also known as Dynorphin-1 or Dyn A is an opioid peptide that acts as a neurotransmitter. It is part of the endorphin enkephalin and dynorphin family of opioid peptides which play significant roles in the modulation of pain and emotion. Dynorphin A consists of 17 amino acids and has a mass of approximately 2 kDa. Its expression is prominent in the central nervous system including the brain and spinal cord where it interacts with kappa-opioid receptors to regulate various physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDynorphin peptides including Dynorphin A act as modulators of nociceptive pathways influencing the perception of pain. As an agonist of kappa-opioid receptors Dynorphin A produces analgesic effects by inhibiting neurotransmitter release in the central nervous system. Although it does not mainly form part of a complex Dynorphin A may stimulate the release or inhibition of other neurotransmitters such as dopamine affecting mood and stress responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nSeveral key physiological activities involve Dynorphin A. It influences the opioid system pathway where it plays important roles in pain modulation and mood regulation. Dynorphin A also interacts with the stress response pathways particularly impacting the hypothalamic-pituitary-adrenal (HPA) axis. It shares pathways with other neurotransmitters and proteins such as endorphins and enkephalins which also target opioid receptors.\u003cbr\u003e\nDynorphin A relates to conditions like addiction and depression. It contributes to the dysregulation of neurotransmitter systems which is a factor in these disorders. Dynorphin A modulates dopamine release involved in reward pathways influencing addiction development. In mood disorders it connects with stress hormones and peptides affecting mental health outcomes. Associations with proteins like corticotropin-releasing factor further link it to how the body manages stress potentially contributing to depressive states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850434334889,"sku":"ab319045","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab319045","provider":"Iright","version":"1.0","type":"link"}