{"product_id":"abcam-ab319109","title":"Abcam, ab319109, Anti-TCF-3\/TCF7L1 antibody [EPR28832-90]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal TCF3 \/ E2A antibody. Suitable for Dot, WB and reacts with Synthetic peptide - Human, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28832-90,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Dot, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTCF-3 also known as TCF7L1 is a high-mobility group (HMG) box transcription factor with a molecular mass of approximately 57 kDa. This protein predominantly serves as a transcriptional repressor and is part of the TCF\/LEF family involved in the Wnt signaling pathway. TCF-3 shows expression in various tissues particularly in embryonic development stages. It mediates transcriptional repression by recruiting co-repressors and chromatin remodeling factors.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTCF-3\/TCF7L1 regulates gene expression critical for cell fate decisions. It is part of a transcriptional complex capable of interacting with beta-catenin. The protein binds to specific DNA sequences and controls the transcription of target genes. Its activity impacts stem cell pluripotency and differentiation playing essential roles in development and cell lineage specification.\u003cbr\u003e\nPathways\u003cbr\u003e\nTCF-3 serves critical roles within the canonical Wnt signaling pathway. It interacts with beta-catenin to modulate transcriptional outcomes. In the absence of Wnt signals TCF-3 represses target genes but it can activate them when Wnt signals stabilize beta-catenin. This pathway is important in embryogenesis and cellular differentiation. TCF-3 also relates functionally to other TCF\/LEF family members which may partially compensate for TCF-3 function in certain contexts.\u003cbr\u003e\nTCF-3 involvement in cancer and congenital malformations has been identified. Altered TCF-3 expression or function contributes to tumorigenesis through deregulation of Wnt pathway targets affecting cell proliferation and apoptosis. In some cancers interactions with proteins like beta-catenin lead to aberrant gene activation. Additionally mutations or dysregulation of TCF-3 are associated with developmental disorders due to its pivotal role in embryonic development processes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850458058921,"sku":"ab319109","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab319109","provider":"Iright","version":"1.0","type":"link"}