{"product_id":"abcam-ab320836","title":"Abcam, ab320836, Anti-Influenza A Virus PB2 protein antibody [EPR29356-84] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PB2 antibody. Carrier free. Suitable for WB, IHC-P, ICC\/IF and reacts with Transfected cell lysate - Influenza A virus (A\/Puerto Rico\/8\/1934(H1N1)), Transfected cell line - Influenza A virus (A\/Puerto Rico\/8\/1934(H1N1)) samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR29356-84,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Influenza A virus (A\/Puerto Rico\/8\/1934(H1N1)),\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab320836 is the carrier-free version of\u003cbr\u003e\nab320835\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nInfluenza A Polymerase basic protein 2 also known as PB2 protein plays an important mechanical role in the viral RNA polymerase complex which is necessary for viral replication. This protein has a molecular mass of approximately 87 kDa. PB2 is expressed within infected host cells and is a component of the influenza A virus polymerase complex along with PA and PB1 proteins. The PB2 target is essential for the transcription and replication phase in the viral lifecycle allowing the virus to hijack the host cell machinery for viral propagation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPB2 protein is part of the heterotrimeric RNA polymerase complex which is critical for the influenza virus's ability to replicate. The polymerase complex includes PA PB1 and PB2 proteins where PB2 protein plays a role in cap-snatching a mechanism to steal host mRNA caps for viral mRNA synthesis. This enables the influenza virus to synthesize its own proteins in the host cytoplasm facilitating efficient viral replication and protein expression.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe PB2 protein functions prominently within the viral replication cycle of the influenza A virus. It is intricately linked with the host's mRNA processing pathways as it engages in the cap-snatching mechanism necessary for viral mRNA transcription. PB2 protein works closely with PB1 in the replication pathway where PB1 acts as the RNA-dependent RNA polymerase in conjunction with activities of PB2.\u003cbr\u003e\nPB2 protein plays a significant role in the pathogenicity of influenza A virus infections in humans and animals. Its interactions are pivotal for the adaptation and virulence of the influenza virus leading to significant morbidity during outbreaks. Mutations in the PB2 gene can relate to species adaptation and increased virulence and the protein's function is important for the virus to overcome host defense mechanisms frequently. PB2 interacts with host proteins to moderate host immune responses making it a target for antiviral drug development and treatment strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851877994665,"sku":"ab320836","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab320836","provider":"Iright","version":"1.0","type":"link"}