{"product_id":"abcam-ab321798","title":"Abcam, ab321798, Anti-PSMB5\/MB1 antibody [EPR28990-5] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PSMB5\/MB1 antibody. Carrier free. Suitable for ICC\/IF, WB, IHC-P and reacts with Human, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28990-5,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Unsuitable for mouse ICC\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab321798 is the carrier-free version of\u003cbr\u003e\nab321797\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPSMB5 also known as MB1 or β5 is a subunit of the 20S proteasome complex with a molecular mass of approximately 28 kDa. This protein functions as a chymotrypsin-like peptidase that is important for protein degradation. It is expressed in various tissues throughout the body particularly in those with high protein turnover.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPSMB5 plays a significant role in regulating protein homeostasis within the cell. It forms part of the core 20S proteasome complex where its enzymatic activity facilitates the breakdown of ubiquitinated proteins into smaller peptides. This protein degradation is essential for many cellular processes including the removal of damaged or misfolded proteins therefore maintaining cellular function.\u003cbr\u003e\nPathways\u003cbr\u003e\nPSMB5 is integral to the ubiquitin-proteasome pathway which is important for protein recycling and quality control within cells. This pathway involves the tagging of proteins with ubiquitin and their subsequent degradation by the proteasome. PSMB5 interacts with other proteasome subunits like β1 and β2 contributing to a functional protein breakdown machinery. Dysregulation of this pathway can lead to the accumulation of unwanted proteins and affect cellular health.\u003cbr\u003e\nAlterations in PSMB5 function have been implicated in the development of cancer and neurodegenerative diseases. Cancer cells often exhibit altered proteasome activity where PSMB5 may contribute to the survival and proliferation of these cells. In neurodegenerative diseases like Alzheimer's impairments in protein degradation pathways including PSMB5 can lead to protein aggregation and toxicity. Researchers are exploring how PSMB5 interacts with other proteins within these contexts to better understand its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851841065129,"sku":"ab321798","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab321798","provider":"Iright","version":"1.0","type":"link"}