{"product_id":"abcam-ab321955","title":"Abcam, ab321955, BOND RX - Anti-B7H4 antibody [EPR20236]","description":"\u003cp\u003eSize: 1Kit\u003cbr\u003e\nRabbit Recombinant Monoclonal B7H4 antibody. Suitable for detection of B7H4 in IHC. Suitable for Human samples. This product is a bundle of 2 x BOND Titration Containers (with 6mL inserts) along with 100 uL vial of Anti-B7H4 antibody [EPR20236] - ab209242. - Validated on the Leica BOND RX automated IHC staining platform for CXCR4 IHC - EPR20236 clone is cited in over 13 publications - Using biophysical QC, antibody identity is confirmed at a molecular level for unrivaled batch-batch consistency\u003cbr\u003e\nProduct details:\u003cbr\u003e\nThis product is a bundle of 2 x BOND Titration Containers (with 6mL inserts) along with 100 uL vial of Anti-B7H4 antibody [EPR20236] -\u003cbr\u003e\nab209242\u003cbr\u003e\nAdditional Titration Inserts can be purchased from Leica Biosystems, using OPT9719 (box of 50). Or Titration Container\/Insert Kit, using OPT9049 (box of 10\/50).\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nB7-H4 also known as VTCN1 or B7x is a member of the B7 family of immunoregulatory proteins. It has an approximate molecular mass of 50 kDa. B7-H4 expression is detected on the surface of various cells including B cells T cells monocytes and some cancer cells. Its expression is often inducible; immune cells can express B7-H4 in response to specific conditions or signals in the environment.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nB7-H4 acts as an immune checkpoint molecule that negatively regulates T cell immunity. It does not form a known complex with other proteins but instead interacts directly with T cells. By inhibiting T cell activation and proliferation B7-H4 contributes to the regulation of immune responses helping to maintain self-tolerance and prevent autoimmunity.\u003cbr\u003e\nPathways\u003cbr\u003e\nB7-H4 is involved in the regulation of immune checkpoints prominently in the pathways related to immune tolerance and suppression. It plays a critical role in the pathways that modulate tumor evasion of the immune system. B7-H4 is related to other immune checkpoint proteins such as PD-L1 which are also pivotal in immune regulation and therapy targets.\u003cbr\u003e\nB7-H4 is connected to cancer progression and autoimmune conditions. Overexpression of B7-H4 in certain cancers such as ovarian and breast cancer associates with tumor immune evasion allowing tumors to grow unchecked by the immune system. Its expression links with proteins like CTLA-4 in maintaining immune suppression. B7-H4 modifications could serve as a potential target in cancer immunotherapy aiming to enhance the immune system's ability to combat malignancies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843614986409,"sku":"ab321955","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab321955","provider":"Iright","version":"1.0","type":"link"}