{"product_id":"abcam-ab322055","title":"Abcam, ab322055, Anti-ATP6V1B2 antibody [EPR28916-13]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ATP6V1B2 antibody. Suitable for Dot, IHC-P, WB and reacts with Transfected cell lysate - Human, Human, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28916-13,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse,\u003cbr\u003e\nApplications:Dot, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Unsuitable for mouse TMA.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nATP6V1B2 also known as V-type proton ATPase subunit B2 is an essential component of the vacuolar ATPase (V-ATPase) complex. It weighs approximately 56 kDa. This protein is responsible for the hydrolysis of ATP supplying energy for proton translocation across membranes. ATP6V1B2 is heavily expressed in various tissues including the brain and kidney. As part of the V1 domain of the V-ATPase it plays an important role in regulating intracellular pH.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nATP6V1B2 contributes to several key processes by enabling proton transport critical for organelle acidification. It is a component of the V-ATPase complex a multi-subunit complex important for the acidification of intracellular compartments. Organelle acidification affects processes like protein degradation neurotransmitter loading and receptor-mediated endocytosis. ATP6V1B2 specifically aids in the stabilization and assembly of the V-ATPase complex ensuring effective proton pumping activity in diverse cellular environments.\u003cbr\u003e\nPathways\u003cbr\u003e\nATP6V1B2 plays a significant role in both endocytic and autophagic pathways. The endocytic pathway integrates proteins such as clathrin and dynamin which are important for the internalization and recycling of membrane components. In autophagy ATP6V1B2 assists in the fusion of autophagosomes with lysosomes influencing cellular homeostasis and response to nutrient deprivation. These pathways are integral for maintaining cellular energy balance growth and survival.\u003cbr\u003e\nATP6V1B2 has associations with conditions such as dominant and recessive cutis laxa type II and Zimmermann-Laband syndrome. These diseases often display craniofacial abnormalities and variable connective tissue symptoms. Connections with proteins like ATP6V1A have been identified which also participate in similar disorders due to shared structural roles in maintaining proper V-ATPase complex function. Understanding these links can further research into targeted therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850343174313,"sku":"ab322055","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab322055","provider":"Iright","version":"1.0","type":"link"}