{"product_id":"abcam-ab32413","title":"Abcam, ab32413, Anti-RSK1 p90 (phospho T359) antibody [E238]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nAnti-RSK1 p90 (phospho T359) antibody [E238] (ab32413) is a rabbit monoclonal antibody detecting RSK1 p90 in  Western Blot, IP, IHC-P, ELISA, Dot Blot . Suitable for  Human, Mouse . - Biophysical QC for unrivalled batch-batch consistency - Over 20 publications - Trusted since 2006\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:E238,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:Dot, IHC-P, IP, WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody is specific for human RSK1 p90 phoshorylated on Threonine 359. 80% identities with RSK3 p90 (pT365+pS369), 75% with RSK2 p90 (pT356+pS360) and 74% identities with RSK6 p90 (pT368+pS372)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-RSK1 p90 (phospho T359) antibody [E238] (ab32413) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), ELISA, Dot Blot in Human, Mouse samples.\u003cbr\u003e\nWhat is the molecular weight of RSK1 p90?\u003cbr\u003e\nAnti-RSK1 p90 (phospho T359) [E238] (ab32413) specifically detects a band for RSK1 p90 (UniProt: Q15418) at a molecular weight of 90kDa.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-RSK1 p90 (phospho T359) [E238] (ab32413) was first used in a scientific publication in 2006 and has been cited over 20 times in peer-reviewed journals.\u003cbr\u003e\nReviewed by scientists\u003cbr\u003e\nAnti-RSK1 p90 (phospho T359) [E238] (ab32413) has over 5 independent reviews from customers.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [E238] also available for your convenience: ab32413, PE -\u003cbr\u003e\nab318320\u003cbr\u003e\n, APC -\u003cbr\u003e\nab318423\u003cbr\u003e\n, Alexa Fluor® 488 -\u003cbr\u003e\nab318526\u003cbr\u003e\n, Alexa Fluor® 647 -\u003cbr\u003e\nab318629\u003cbr\u003e\n, Alexa Fluor® 594 -\u003cbr\u003e\nab318732\u003cbr\u003e\n, Alexa Fluor® 555 -\u003cbr\u003e\nab318832\u003cbr\u003e\n, Alexa Fluor® 750 -\u003cbr\u003e\nab321601\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRSK1 also known as p90 ribosomal S6 kinase 1 or p90RSK is a serine\/threonine kinase with an approximate mass of 90 kDa. It belongs to the family of proteins that integrate signals from various extracellular stimuli. This kinase is expressed in diverse tissues including brain lung liver and skeletal muscle. At the molecular level RSK1 phosphorylates various target proteins that are involved in regulating cellular growth and survival. Its activity is regulated by phosphorylation events that occur at specific sites such as Serine 238 (E238 in some literature) which are critical for its function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRSK1 plays a fundamental role in cell proliferation and differentiation in the context of the p90 protein weight. It is an important component of the mitogen-activated protein kinase (MAPK) signaling pathway and forms part of multi-protein complexes that facilitate its activation and function. RSK1 influences various biological processes by phosphorylating transcription factors histone proteins and other kinases thereby regulating gene expression and protein synthesis. These actions highlight its influence in maintaining cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nRSK1 p90 interacts significantly with the MAPK\/ERK and PI3K\/AKT pathways. It acts downstream of ERK where it receives activating signals that enable it to phosphorylate substrates within the cell. This role supports its interaction with proteins like Akt and mTOR which are critical mediators of cell growth signals. The interplay between these pathways enables cells to respond to growth factors and stress contributing to the regulation of development and metabolism.\u003cbr\u003e\nRSK1 is implicated in the progression of cancer and neurological disorders. In cancer abnormal RSK1 signaling can lead to unchecked cell growth and survival where it often interfaces with proteins such as C-RAF and BCL-2 to promote oncogenic pathways. In neurological disorders RSK1 influences pathways that regulate neuron survival and plasticity connecting it to proteins like CREB. Understanding RSK1's role in these conditions can provide insight into targeted therapies that may mitigate these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844075638953,"sku":"ab32413","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab32413","provider":"Iright","version":"1.0","type":"link"}