{"product_id":"abcam-ab3243","title":"Abcam, ab3243, Anti-TRPM8 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal TRPM8 antibody. Suitable for WB, IHC-P and reacts with African green monkey, Human samples. Cited in 42 publications. Immunogen corresponding to Synthetic Peptide within Human TRPM8.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, African green monkey,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human TRPM8. The exact immunogen used to generate this antibody is proprietary information.Q7Z2W7,\u003cbr\u003e\nSpecificity:Reacts with residues 278-292 and the C terminus sequence of the human trpm8 protein.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Purification notes-Immunogen affinity purified., Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRPM8 also known as Transient Receptor Potential Cation Channel Subfamily M Member 8 or Menthol Receptor is a cold-activated ion channel. TRPM8 has a molecular weight of approximately 128 kDa. This protein mainly localizes on the plasma membrane of sensory neurons within the dorsal root and trigeminal ganglia. It plays a mechanical role by facilitating the influx of Ca2+ and Na+ ions leading to depolarization which contributes to cold sensation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTRPM8 functions as a critical sensor for detecting temperatures below 28°C and is activated by natural compounds like menthol and icilin. It does not form part of any known protein complexes but can interact with lipids in the cell membrane influencing its activity. It serves in thermosensation providing an immediate response to environmental temperature changes thereby playing an important role in maintaining body homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nTRPM8 is integral to thermoregulatory pathways specifically involved in cold sensation. It participates in the pathway related to the TRP channel family which includes related channels like TRPV1 known for heat sensation. Another pathway is the nociceptive pathway where TRPM8 participates in transmitting signals associated with pain that is triggered by cold temperatures.\u003cbr\u003e\nTRPM8 has been linked to conditions such as neuropathic pain and prostate cancer. In neuropathic pain TRPM8 can exacerbate pain sensation due to its heightened activation. In prostate cancer elevated levels of TRPM8 expression have been observed connecting it to disease progression. The protein's relation to these disorders often associates it closely with other proteins like TRPV1 in pain mechanisms and androgen receptors in prostate cancer.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855807860905,"sku":"ab3243","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab3243","provider":"Iright","version":"1.0","type":"link"}