{"product_id":"abcam-ab33298","title":"Abcam, ab33298, Anti-Tbx2 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal TBX2 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 8 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:From Mar 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTbx2 also known as T-box 2 is a transcription factor with a molecular weight of approximately 80 kDa. This protein is a member of the T-box family which is known for regulating gene expression through DNA binding. Tbx2 plays a role in controlling developmental processes by suppressing the expression of certain target genes. It is expressed in various tissues including heart limbs and craniofacial regions during embryonic development.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis transcription factor is influential in cellular proliferation and developmental growth. It acts as a transcriptional repressor and participates in developmental processes such as osteogenesis and limb formation. Tbx2 is commonly found in complexes with other proteins that help modulate its effects on gene expression particularly during the early stages of embryogenesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nT-box 2 interacts importantly within the Wnt signaling and Sonic Hedgehog (Shh) pathways. These pathways are vital in developmental signaling where Tbx2 works with proteins such as beta-catenin in Wnt signaling influencing gene transcription linked to cell division and differentiation. Tbx2's role in these pathways affects the expression of key genes involved in tissue patterning and development.\u003cbr\u003e\nTbx2 has connections to cancer and developmental disorders. Its overexpression can lead to unchecked cell proliferation implicating it in melanoma and other cancers. Additionally its role in developmental processes links Tbx2 to disorders such as Holt-Oram syndrome through interactions with Tbx5 another member of the T-box family. Understanding Tbx2's precise functions and interactions is essential for developing therapeutic strategies targeting these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850091450537,"sku":"ab33298","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab33298","provider":"Iright","version":"1.0","type":"link"}