{"product_id":"abcam-ab34793","title":"Abcam, ab34793, Anti-PEP Carboxylase antibody","description":"\u003cp\u003eSize: 500µL\u003cbr\u003e\nRabbit Polyclonal CAPP1 antibody. Suitable for IP, ELISA, WB and reacts with Corn samples. Cited in 10 publications. Immunogen corresponding to Chemical \/ Small Molecule corresponding to PEP Carboxylase.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Corn,\u003cbr\u003e\nApplications:WB, IP, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nSpecificity:Cross reactivity against Phospho-enol-pyruvate Carboxylase from other tissues and species may occur but have not been specifically determined.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAntibody concentration was determined by Refractometry.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Whole antiserum, Purification notes-ab34793 was prepared from monospecific antiserum by a delipidation and defibrination., Storage buffer-Preservative: 0.01% Sodium azide Constituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPEP Carboxylase also known as phosphoenolpyruvate carboxylase or PEP-carboxylase is an enzyme that catalyzes the conversion of phosphoenolpyruvate (PEP) to oxaloacetate. This enzyme is important for fixing carbon in photosynthetic pathways. The enzyme's molecular mass is approximately 100 kDa and it primarily expresses in plant tissues particularly those involved in photosynthesis such as mesophyll cells. It also appears in some bacteria where it plays a role in carbon metabolism.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPhosphoenolpyruvate carboxylase plays a significant role in the fixation of carbon dioxide contributing to C4 and CAM photosynthesis mechanisms where it takes part in the assimilation of inorganic carbon into organic compounds. It functions as a homotetramer where each subunit contributes to overall enzyme activity. This enzyme not only aids in photosynthesis but also participates in processes like gluconeogenesis and anaplerotic reactions in non-photosynthetic organisms highlighting its diverse roles across species.\u003cbr\u003e\nPathways\u003cbr\u003e\nPhosphoenolpyruvate carboxylase's role is integral to both the C4 and CAM photosynthetic pathways. In these pathways it works alongside other proteins such as Rubisco to mitigate photorespiration and increase photosynthetic efficiency especially under conditions of drought or high temperatures. This enzyme also intersects with the glycolysis and gluconeogenesis pathways connecting to intermediary metabolism through shared molecules like phosphoenolpyruvate and oxaloacetate linking carbohydrate metabolism to broader metabolic networks.\u003cbr\u003e\nPhosphoenolpyruvate carboxylase may relate to metabolic disorders due to its central role in gluconeogenesis and anaplerosis. Dysregulation of this enzyme's activity can potentially impact conditions such as diabetes where gluconeogenesis plays a pivotal role in glucose production. Moreover certain microbes engineered with this enzyme hold potential in bioenergy applications and may influence pathogenicity in bacterial infections linking PEP-carboxylase function indirectly to infectious disease dynamics. Its interactions with proteins involved in metabolism suggests a broader impact that goes beyond plant biology possibly affecting human health through metabolic balances.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853957157033,"sku":"ab34793","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab34793","provider":"Iright","version":"1.0","type":"link"}