{"product_id":"abcam-ab3905","title":"Abcam, ab3905, Anti-DOPA Decarboxylase\/DDC antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal DOPA Decarboxylase\/DDC antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 39 publications. Immunogen corresponding to Recombinant Fragment Protein within Cow DDC.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Cow DDC. The exact immunogen used to generate this antibody is proprietary information.P27718\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.5Preservative: 0.1% Sodium azideConstituents: PBS, 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.238% HEPES, 0.1% BSA, 0.05% Sorbitan monolaurate, ethoxylated, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDOPA Decarboxylase also known as DDC or aromatic L-amino acid decarboxylase is an enzyme critical in neurotransmitter production. It has a molecular mass of approximately 54 kDa. DOPA Decarboxylase converts L-DOPA to dopamine and 5-HTP to serotonin. This enzyme is expressed in tissues like the brain liver and kidney with high activity levels in the central nervous system.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDOPA Decarboxylase plays an essential role in the synthesis of neurotransmitters such as dopamine and serotonin. It functions as part of the enzymatic conversion process and is not typically associated with larger complexes. The availability and activity of DDC directly influence the levels of these neurotransmitters affecting various physiological responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nDOPA Decarboxylase participates in the catecholamine biosynthesis pathway. This pathway is important for regulating body functions like mood motivation and fine motor control. DDC activity connects it with proteins such as tyrosine hydroxylase which provides the precursor L-DOPA for dopamine synthesis. Additionally it is involved in the serotonin biosynthesis pathway alongside tryptophan hydroxylase.\u003cbr\u003e\nDOPA Decarboxylase shows significant relevance to conditions like Parkinson's disease and depression. Reduced DDC activity results in decreased dopamine levels which contribute to Parkinson’s symptoms. In depression altered DDC function affects serotonin levels. Its interaction with proteins like monoamine oxidase also plays a role in these disorders due to their involvement in neurotransmitter metabolism.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855796195497,"sku":"ab3905","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab3905","provider":"Iright","version":"1.0","type":"link"}