{"product_id":"abcam-ab40877","title":"Abcam, ab40877, Anti-PPP1R1A antibody [EP902Y]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nAnti-PPP1R1A antibody [EP902Y] (ab40877) is a rabbit monoclonal antibody detecting PPP1R1A in  Western Blot, Flow Cytometry (Intra), Flow Cytometry, IHC-P, ICC\/IF . Suitable for  Human, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 10 publications - Trusted since 2006\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP902Y,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-PPP1R1A antibody [EP902Y] (ab40877) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry\/immunofluorescence (ICC\/IF) in Human, Rat samples.\u003cbr\u003e\nWhat is the molecular weight of PPP1R1A?\u003cbr\u003e\nAnti-PPP1R1A [EP902Y] (ab40877) specifically detects a band for PPP1R1A (UniProt: Q13522) at a molecular weight of 19kDa.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-PPP1R1A [EP902Y] (ab40877) was first used in a scientific publication in 2006 and has been cited over 10 times in peer-reviewed journals.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EP902Y] also available for your convenience: ab40877, Carrier free -\u003cbr\u003e\nab247299\u003cbr\u003e\n, PE -\u003cbr\u003e\nab306211\u003cbr\u003e\n, APC -\u003cbr\u003e\nab306212\u003cbr\u003e\n, HRP -\u003cbr\u003e\nab306213\u003cbr\u003e\n, Alkaline Phosphatase -\u003cbr\u003e\nab308878\u003cbr\u003e\n, Alexa Fluor® 488 -\u003cbr\u003e\nab309800\u003cbr\u003e\n, Alexa Fluor® 647 -\u003cbr\u003e\nab310170\u003cbr\u003e\n, Alexa Fluor® 594 -\u003cbr\u003e\nab310604\u003cbr\u003e\n, Alexa Fluor® 555 -\u003cbr\u003e\nab312132\u003cbr\u003e\n, Alexa Fluor® 568 -\u003cbr\u003e\nab312619\u003cbr\u003e\n, Alexa Fluor® 750 -\u003cbr\u003e\nab321627\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein phosphatase 1 regulatory inhibitor subunit 1A also known as PPP1R1A or inhibitor-1 (I-1) plays a significant role in cellular regulation as a phosphatase inhibitor. Mechanically it regulates the activity of protein phosphatase 1 (PP1) an essential enzyme in various cellular processes. Its molecular weight is approximately 19 kDa. PPP1R1A is expressed in many tissues showing notable levels in cardiac and skeletal muscle where it helps modulate responses to various stimuli.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPPP1R1A modulates signaling pathways by influencing the dephosphorylation of substrates which is a critical step in signal transduction. It is not typically part of a complex but interacts closely with protein phosphatase 1. This interaction allows for the effective regulation of phosphorylation states within cells impacting cell cycle control muscle contraction glycogen metabolism and more. Its regulatory capabilities are important for maintaining cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe regulatory activities of PPP1R1A significantly impact the cAMP signaling pathway and the regulation of glycogen metabolism. Within the cAMP pathway PPP1R1A regulates the activity of PP1 influencing processes like muscle contraction and gene expression. It interacts with proteins such as PKA which phosphorylates PPP1R1A activating its inhibitory function. This regulation affects downstream cellular activities by modulating phosphorylation levels of key substrates within these pathways.\u003cbr\u003e\nAlterations in PPP1R1A expression or function have implications in cardiac diseases and diabetes. Increased or decreased activity of PPP1R1A can disrupt normal heart function due to its regulatory role in cardiac muscle contraction. Altered regulation within the cAMP and glycogen metabolism pathways can contribute to metabolic disorders like diabetes. Interactions with proteins such as PP1 and PKA are critical for these conditions highlighting PPP1R1A's role in disease progression and potential therapeutic targeting.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844181217449,"sku":"ab40877","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab40877","provider":"Iright","version":"1.0","type":"link"}