{"product_id":"abcam-ab50148","title":"Abcam, ab50148, Anti-beta Glucuronidase (GUS) antibody - Aminoterminal end","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal beta glucuronidase (GUSB) antibody. Suitable for WB and reacts with Escherichia coli samples. Cited in 11 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Escherichia coli,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nBeta Glucuronidase (GUS) sometimes referred to as E. coli Beta-Glucuronidase or GUS Beta is an enzyme involved in hydrolyzing the beta-D-glucuronic acid residues from the non-reducing end of glycosaminoglycans. This enzymatic function makes it vital for the breakdown and recycling of complex carbohydrates in cells. GUS has a molecular mass of approximately 290 kDa and is expressed in various tissues with high levels observed in the liver and kidneys which are integral components of excretory processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nBeta Glucuronidase plays an important role in the lysosomal degradation of glycosaminoglycans. This process helps remove waste substances from the body effectively and deficiency in this enzyme may lead to the accumulation of undegraded molecules. Not part of a large complex GUS functions independently as a single protein catalytic unit. Researchers often employ the GUS assay to monitor its activity in analytical and clinical contexts indicating its importance in cellular metabolism research.\u003cbr\u003e\nPathways\u003cbr\u003e\nBeta Glucuronidase is integral to the glycosaminoglycan degradation pathway which is essential for catabolizing heparan sulfate and dermatan sulfate. This pathway is significant for cellular turnover and tissue remodeling. Related proteins within this metabolic framework include other lysosomal hydrolases such as acid alpha-glucosidase which work concertedly to maintain cellular homeostasis by degrading complex carbohydrates.\u003cbr\u003e\nDeficient activity of Beta Glucuronidase links to mucopolysaccharidosis (MPS) specifically MPS VII also known as Sly syndrome. This genetic condition results in various systemic complications including skeletal and developmental abnormalities. The enzyme's malfunction may also relate to liver diseases as improper breakdown of glucuronides can impact liver function. Studies investigate the connection of Beta Glucuronidase with other lysosomal storage disorder proteins to better understand their collective impact on disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854418661545,"sku":"ab50148","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab50148","provider":"Iright","version":"1.0","type":"link"}