{"product_id":"abcam-ab51523","title":"Abcam, ab51523, Anti-SLIRP antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal SLIRP antibody. Suitable for IHC-P, ICC\/IF, WB and reacts with Human samples. Cited in 11 publications. Immunogen corresponding to Synthetic Peptide within Human SLIRP.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human SLIRP. The exact immunogen used to generate this antibody is proprietary information.Q9GZT3\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4 Preservative: 0.05% Sodium azide Constituents: Tris glycine, 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSLIRP also known as SRA stem-loop interacting RNA binding protein is a small protein with a molecular mass of approximately 12 kDa. It has widespread expression in various tissues including the liver heart and muscle. SLIRP functions mainly in the mitochondria binding to RNA elements. This protein engages with the stem-loop structure in the SRA RNA influencing its stability and activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSLIRP participates in transcriptional regulation through interaction with the steroid receptor RNA activator (SRA). It is an integral part of ribonucleoprotein complexes. SLIRP modulates gene expression by binding to nuclear receptors such as estrogen and androgen receptors. Through its RNA-binding ability it affects mitochondrial gene transcripts and subsequently influences mitochondrial function.\u003cbr\u003e\nPathways\u003cbr\u003e\nSLIRP plays a role in the modulation of nuclear receptor signaling and mitochondrial biogenesis pathways. In the nuclear receptor signaling SLIRP interacts with SRA RNA impacting the activity of nuclear receptors. In mitochondrial biogenesis it is linked to the maintenance of mitochondrial gene expression. Proteins like PGC-1α which is an important regulator of energy metabolism interacts indirectly through the linked pathways.\u003cbr\u003e\nSLIRP has implications in breast cancer and metabolic disorders. In breast cancer SLIRP's interaction with SRA RNA influences the behavior of estrogen receptors potentially affecting cancer progression. In metabolic disorders alterations in SLIRP levels can affect mitochondrial function connecting it to conditions like obesity or type 2 diabetes. Proteins such as PPARγ an important player in metabolic regulation may interplay with SLIRP functions in these contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848629506217,"sku":"ab51523","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab51523","provider":"Iright","version":"1.0","type":"link"}