{"product_id":"abcam-ab5207","title":"Abcam, ab5207, Anti-Piwi antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal PIWI antibody. Suitable for WB and reacts with Drosophila melanogaster samples. Cited in 9 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Drosophila melanogaster,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPiwi also known as P-element Induced WImpy testis belongs to the Argonaute family of proteins and has a molecular mass around 100 kDa. Piwi is mainly expressed in the germline cells and plays an important role in maintaining stem cell populations. The primary function of Piwi involves the interaction with piRNAs (Piwi-interacting RNAs) which are small non-coding RNAs. This interaction helps in the suppression of transposable element activity ensuring genome stability in the germ cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPiwi interacts with piRNAs to form a silencing complex that regulates gene expression. This protein plays an important role in germ cell development and differentiation. By silencing transposon elements the Piwi-piRNA complex prevents potentially harmful genomic instability. Beyond germ cells Piwi has been seen to play roles in some somatic tissues indicating its broader biological significance.\u003cbr\u003e\nPathways\u003cbr\u003e\nPiwi engages in the RNA interference (RNAi) pathway where it works together with other Argonaute proteins to mediate gene silencing. In the piRNA pathway Piwi collaborates with related proteins like Ago3 and Aubergine to ensure proper gene regulation during gametogenesis. These interactions are essential for the maintenance of genetic integrity by repressing the activity of transposable elements.\u003cbr\u003e\nPiwi has associations with germ cell tumors and some forms of cancer. Dysregulation of the Piwi-piRNA pathway can contribute to abnormal cell growth implicating Piwi in oncogenic processes. Piwi-related proteins connect to these disease states as seen in interactions with members of the Argonaute family which have broader roles in gene regulation and cancer biology. Understanding Piwi's role offers potential therapeutic targets for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854415253673,"sku":"ab5207","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab5207","provider":"Iright","version":"1.0","type":"link"}