{"product_id":"abcam-ab5317","title":"Abcam, ab5317, Anti-Sumo 3 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal SUMO3 antibody. Suitable for WB and reacts with Arabidopsis thaliana samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Arabidopsis thaliana SUMO3.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Arabidopsis thaliana,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Arabidopsis thaliana SUMO3.Q9FLP5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Whole antiserum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSumo 3 also referred to as Small Ubiquitin-like Modifier 3 is a protein with a mass of approximately 11 kDa. It belongs to the SUMO family which modifies other proteins by attaching to them through a process called SUMOylation. Sumo 3 gets expressed widely in many tissues including the brain heart and skeletal muscles. It plays an important role in cellular processes such as nuclear-cytosolic transport transcriptional regulation and DNA repair.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSumo 3 functions in post-translational modification of proteins and often forms part of protein complexes. This modification can alter the protein's localization stability and activity. Sumo 3 activity influences cell cycle progression mitosis and stress response. SUMOylation including Sumo 3 adjusts protein interactions and functions impacting cellular homeostasis and modulation of transcription factors.\u003cbr\u003e\nPathways\u003cbr\u003e\nSumo 3 participates in the DNA repair and cellular stress response pathways. Through these pathways Sumo 3 closely interacts with proteins such as P53 an important protein in cell cycle regulation and apoptosis. Sumo 3 aids in facilitating DNA damage repair and protecting cells from apoptosis under stress helping maintain genomic integrity.\u003cbr\u003e\nSumo 3 involvement has a relation to cancer and neurodegenerative disease. Alterations in SUMOylation patterns involving Sumo 3 can lead to cancer development due to ineffective DNA repair and apoptosis. Furthermore in neurodegenerative disease Sumo 3 modulates protein aggregation processes increasing or reducing accumulation of neurotoxic proteins. Sumo 3 often interacts with proteins like huntingtin in Huntington's disease influencing disease progression through modulation of protein aggregation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850166554793,"sku":"ab5317","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab5317","provider":"Iright","version":"1.0","type":"link"}