{"product_id":"abcam-ab5665","title":"Abcam, ab5665, Anti-PDE6D antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal PDE6D antibody. Suitable for ICC, WB, ICC\/IF, IHC-Fr and reacts with Mouse, Pig, Human, Dog, Cow, Sheep samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Mouse Pde6d aa 1-50.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Cow, Human, Pig, Sheep, Dog,\u003cbr\u003e\nApplications:IHC-Fr, WB, ICC\/IF, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Mouse Pde6d aa 1-50. The exact immunogen used to generate this antibody is proprietary information.O55057,\u003cbr\u003e\nSpecificity:This antibody does not detect other PDE6 isoforms.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe PDE6D protein also known as Phosphodiesterase Delta or PDE6 delta serves a mechanical function as a prenyl-binding protein. It facilitates the release of prenylated proteins from cellular membranes allowing their proper trafficking within the cell. PDE6D has a molecular mass of approximately 17 kDa and is a part of the larger phosphodiesterase family. Expression of this target occurs mainly in retinal photoreceptor cells but is also found in several other tissues such as the brain and kidneys.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPDE6D plays a role in the proper localization and function of various prenylated proteins contributing to retinal function. It is important for ciliary targeting allowing proteins like the small GTPase Ras and the retinitis pigmentosa protein RPGR to localize correctly. PDE6D itself does not form part of a larger complex but facilitates the interaction between proteins and other cell components ensuring that cellular processes proceed as needed.\u003cbr\u003e\nPathways\u003cbr\u003e\nPDE6D functions as an important player in small GTPase-mediated signal transduction. This protein interacts with the Ras superfamily of small GTPases important for intracellular signaling pathways. It plays a role in processes such as cell growth differentiation and apoptosis. The proper functioning of PDE6D ensures that prenylated proteins like Ras which are also implicated in these pathways are effectively transported to their destinations within the cell.\u003cbr\u003e\nPDE6D has been linked to retinitis pigmentosa a degenerative eye disease leading to retinal dysfunction. Mutations in the PDE6D gene disrupt the proper trafficking of prenylated proteins including RPGR which is essential for photoreceptor cell survival and function. Additionally PDE6D may also play a role in Joubert syndrome where it affects the localization of proteins necessary for proper ciliary function contributing to the disorders observed in this syndrome.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860533072041,"sku":"ab5665","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab5665","provider":"Iright","version":"1.0","type":"link"}