{"product_id":"abcam-ab57274","title":"Abcam, ab57274, Anti-HN1 antibody [2C8]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nAnti-HN1 antibody [2C8] (ab57274) is a mouse monoclonal antibody detecting HN1 in  Western Blot . Suitable for  Human . - Trusted since 2007\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:2C8,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human JPT1.Q9UK76\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-HN1 antibody [2C8] (ab57274) is a mouse monoclonal antibody and is validated for use in Western Blot (WB) in Human samples.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.4, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHN1 also known as Hematological and Neurological Expressed 1 protein is a small protein with a mass of approximately 10 kDa. It expresses in various tissues mainly in hematopoietic and neurological cells. Researchers also identified its expression in some cancerous tissues which suggests its potential role in tumor biology. HN1 exhibits a notable presence in cytoplasmic and nuclear compartments indicating its involvement in multiple cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nExperts believe HN1 participates in cellular development and differentiation. It does not function alone but interacts with other proteins within a larger complex affecting intracellular signaling. This interaction hints at the protein's role in supporting the regulation of cellular growth and hematopoiesis. In addition HN1 influences cellular responses to stress which further supports its relevance in development and disease.\u003cbr\u003e\nPathways\u003cbr\u003e\nHN1 integrates into the Jak-STAT signaling pathway and possibly the Notch signaling pathway. This association with significant signaling pathways implies its role in modulating gene expression linked to cell proliferation and differentiation. HN1 also shows interactions with other proteins in these pathways such as STAT3 suggesting collaborative involvement in regulating cellular responses to external stimuli.\u003cbr\u003e\nScientists have linked HN1 to cancer and neurodegenerative diseases. Its upregulation in various cancer types like breast cancer indicates a potential role in tumor cell proliferation and survival. Additionally in neurodegenerative conditions changes in HN1 expression suggest it might contribute to neuronal dysfunction. Connections to related proteins like BCL2 involved in cell survival highlight HN1’s implications in both cancer progression and neurodegenerative pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854768722089,"sku":"ab57274","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab57274","provider":"Iright","version":"1.0","type":"link"}