{"product_id":"abcam-ab58881","title":"Abcam, ab58881, Anti-FBH1 antibody [2353C1a]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal FBH1 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FBH1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:2353C1a,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human FBH1. The exact immunogen used to generate this antibody is proprietary information.Q8NFZ0\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum and filtered through a 0.22µm membrane., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 1% BSA, 0.812% Sodium chloride, 0.1312% Sodium phosphate, 0.03% Tripotassium orthophosphate, 0.0225% Potassium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFBH1 also known as F-box helicase 1 is a DNA helicase with a molecular mass of about 120 kDa. It possesses ATPase activity and plays a role in unwinding DNA during replication and repair. FBH1 often localizes to the cell nucleus and shows expression in a variety of human tissues. Scientists also recognize it for its role in maintaining genome integrity particularly during the S-phase of the cell cycle.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFBH1 contributes to the regulation of DNA replication and repair processes. It functions in tandem with other proteins to form a complex that can identify and repair damaged DNA strands. This protein complex is involved in maintaining genomic stability by preventing replication forks from collapsing and assisting in the resolution of DNA supercoiling and entanglements. FBH1 also links to the cellular response to double-strand breaks by promoting homologous recombination repair.\u003cbr\u003e\nPathways\u003cbr\u003e\nFBH1 is closely involved in homologous recombination and DNA damage response pathways. It interacts with proteins such as RAD51 a homologous recombination repair protein and BRCA1 which plays a role in maintaining genomic stability. Through these interactions FBH1 ensures proper DNA repair and cell cycle progression which are critical for preventing genomic instability and tumorigenesis.\u003cbr\u003e\nFBH1 has a notable connection to cancer. Dysregulation of FBH1 may lead to uncontrolled cell division and genomic instability contributing to the development of cancer. Moreover studies have shown that FBH1 interacts with the tumor suppressor protein p53 which plays a critical role in controlling cell growth and apoptosis. Understanding FBH1’s function and its interactions with proteins like p53 could provide insights into therapeutic targets for cancer treatment.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854653411497,"sku":"ab58881","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab58881","provider":"Iright","version":"1.0","type":"link"}