{"product_id":"abcam-ab61426","title":"Abcam, ab61426, Recombinant human TAOK2 protein","description":"\u003cp\u003eSize: 5µg \/ 10µg\u003cbr\u003e\nRecombinant human TAOK2 protein is a Human Fragment protein, in the 1 to 314 aa range, expressed in Baculovirus infected Sf9 cells, with \u0026gt;85%, suitable for SDS-PAGE, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;85% Densitometry,\u003cbr\u003e\nExpression system:Baculovirus infected Sf9 cells,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:Specific activity: 104 nmol\/min\/mg.,\u003cbr\u003e\nAccession:Q9UL54,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.0038% EGTA, 0.00292% EDTA, 0.00174% PMSF\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab64311\u003cbr\u003e\n(Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTAOK2 a serine\/threonine-protein kinase also known as TAO2 is a member of the thousand and one amino acid kinases family. It is a 130 kDa protein that participates in various cellular processes by transferring phosphate groups to serine and threonine residues on substrate proteins. TAOK2 is part of the cytoplasmic signaling pathway and shows expression in different tissues especially in the brain. It plays important roles by interacting with cellular machinery to perform its functions effectively within the cell.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTAOK2 is instrumental in modulating cytoskeletal dynamics impacting processes such as neuron morphology and dendritic branching. TAOK2 associates with complexes involved in microtubule assembly influencing cell division and intracellular transport. Its activity affects neuronal connectivity impacting neural development and synaptic function which are critical in the nervous system. This makes its regulation necessary for normal brain function and development.\u003cbr\u003e\nPathways\u003cbr\u003e\nTAOK2 integrates into the MAPK signaling pathway affecting cell responses to stress and cytokines. This pathway is important for initiating cellular responses to external stimuli such as changes in the environment or cellular damage. TAOK2 phosphorylates other proteins such as MEK3 MEK6 and p38 MAP kinases influencing downstream signaling cascades. It also interacts with proteins involved in the Wnt signaling pathway contributing to cell differentiation proliferation and the maintenance of stem cells.\u003cbr\u003e\nTAOK2 has links to neurodevelopmental disorders and schizophrenia. Mutations and dysregulations in TAOK2 expression correlate with developmental abnormalities in the brain potentially leading to conditions like autism spectrum disorder. Furthermore its interaction with proteins such as DISC1 a schizophrenia-associated protein suggests a role in psychiatric disorders. TAOK2's involvement in altering neural architecture highlights its importance in maintaining neuropsychiatric health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843848753321,"sku":"ab61426","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab61426","provider":"Iright","version":"1.0","type":"link"}