{"product_id":"abcam-ab62334","title":"Abcam, ab62334, Anti-PPP1A\/PPP1CA (phospho T320) antibody [EP1512Y]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Monoclonal PPP1A\/PPP1CA phospho T320 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 30 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP1512Y,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody detects PP1 alpha phosphorylated at Threonine 320.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nProtein phosphatase 1 alpha also known as PPP1A or PPP1CA is a catalytic subunit of protein phosphatase 1 with a molecular weight of approximately 37 kDa. PPP1A plays a role in the dephosphorylation of serine\/threonine residues in various proteins. It is expressed widely in human tissues with significant presence in the brain heart and skeletal muscle. PPP1A is essential for many cellular processes due to its widespread distribution and ability to interact with different substrate proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nProtein phosphatase 1 alpha controls key aspects of cellular function. It often exists as part of complexes with other regulatory proteins which modulate its specificity and activity. These complexes participate in cell cycle regulation muscle contraction protein synthesis and glycogen metabolism. PPP1A's role in forming reversible phosphorylation networks highlights its importance in maintaining cellular homeostasis and responding to various signals.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe role of PPP1A is vital in pathways such as the cell cycle and glycogen metabolism. It interacts with proteins like cyclin-dependent kinases to manage the cell division process and collaborates with glycogen synthase to regulate glycogen synthesis and breakdown. The involvement of PPP1A in these pathways showcases its versatility in influencing cellular metabolism and division processes.\u003cbr\u003e\nProtein phosphatase 1 alpha is linked to cardiac diseases and cancer. Its dysregulation can influence heart muscle contractility contributing to cardiac hypertrophy and heart failure. Additionally abnormal PPP1A activity can impact tumorigenesis through interactions with cancer-related proteins like Akt. Understanding PPP1A's role in these diseases provides insights into potential therapeutic targets for treatment.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850256371881,"sku":"ab62334","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab62334","provider":"Iright","version":"1.0","type":"link"}