{"product_id":"abcam-ab62373","title":"Abcam, ab62373, Anti-beta Dystroglycan antibody [EP2200Y]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal DAG1 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP2200Y,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nRat: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nBeta Dystroglycan also known as β-DG is a transmembrane protein with a molecular mass of approximately 43 kDa. It plays a mechanical role by linking the extracellular matrix to the cytoskeleton acting as a part of the dystrophin-glycoprotein complex. This protein is widely expressed in many tissues including skeletal muscle cardiac muscle and the central nervous system. Beta Dystroglycan serves as a receptor for components like laminin and agrin in the extracellular matrix.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nBeta Dystroglycan acts as a structural and signaling molecule within the dystrophin-glycoprotein complex. This complex stabilizes the sarcolemma during muscle contraction and helps in protecting muscle fibers from injury. Beta Dystroglycan also contributes to cellular signaling pathways by interacting with various intracellular proteins like dystrophin and alpha dystroglycan. It regulates cell adhesion and migration processes critical for tissue maintenance and repair.\u003cbr\u003e\nPathways\u003cbr\u003e\nBeta Dystroglycan plays a critical role in the integrity of the dystrophin-associated glycoprotein complex. It is involved in the AKT signaling pathway which is essential for cellular growth and survival. Moreover beta Dystroglycan interacts closely with proteins such as dystrophin and utrophin facilitating their functions in muscle cells. Its interactions help maintain cell membrane stability and signal transduction processes important for normal cellular functions.\u003cbr\u003e\nBeta Dystroglycan’s dysfunction has been closely linked to muscular dystrophies specifically Duchenne and Becker muscular dystrophies. These conditions involve muscle weakness and degeneration linked to abnormalities in the dystrophin-glycoprotein complex. Additionally aberrant glycosylation and signaling of beta Dystroglycan contribute to cancer progression through altered cell adhesion and migration often involving interactions with proteins like α-dystroglycan.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855873101993,"sku":"ab62373","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab62373","provider":"Iright","version":"1.0","type":"link"}