{"product_id":"abcam-ab6310","title":"Abcam, ab6310, Anti-Collagen III antibody [FH-7A]","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nAnti-Collagen III antibody [FH-7A] (ab6310) is a mouse monoclonal antibody detecting Collagen III in  Western Blot, IHC-P, IHC-Fr, ICC\/IF, ELISA, Dot Blot . Suitable for  Human, Rat . - Clone FH-7A is the most cited clone to Collagen III - Over 170 publications - Trusted since 2002\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:FH-7A,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-Fr, Dot, ELISA, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Native Full Length Protein corresponding to Human COL3A1.P02461,\u003cbr\u003e\nSpecificity:ab6310 specifically recognizes collagen type III from human and rat origin. It does not recognize collagen types I, II, IV, V, VI and X.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAnti-Collagen III antibody [FH-7A] (ab6310) is a House Mouse Monoclonal antibody and is validated for use in Dot, ELISA, ICC\/IF, IHC-Fr, IHC-P, WB in human samples.\u003cbr\u003e\nAnti-Collagen III antibody [FH-7A] (ab6310) has been cited over 172 times in peer reviewed journals and is trusted by the scientific community.\u003cbr\u003e\nAbcams high quality validation processes ensure Anti-Collagen III antibody [FH-7A] (ab6310) has high sensitivity and specificity.\u003cbr\u003e\nAnti-Collagen III antibody [FH-7A] (ab6310) has 13 independent reviews from customers.\u003cbr\u003e\nAnti-Collagen III antibody [FH-7A] (ab6310) specifically detects Collagen III (UniProt ID: P02461; Molecular weight: 95kDa) and is sold in 50 uL selling sizes.\u003cbr\u003e\nCollagen III is a critical fibrillar collagen that plays a significant role in the structural integrity of various tissues, including the skin, lungs, and blood vessels. Alterations in Collagen III expression are associated with several diseases. For instance, mutations in the COL3A1 gene, which encodes Collagen III, can lead to Ehlers-Danlos syndrome type IV, a condition characterized by fragile blood vessels and organs. Additionally, abnormal Collagen III deposition is implicated in fibrotic diseases, such as liver cirrhosis and pulmonary fibrosis, where excessive collagen accumulation disrupts normal tissue architecture. Understanding Collagen III's role in these diseases is crucial for developing targeted therapies and improving patient outcomes.\u003cbr\u003e\nType III collagen, [a1(III)]3 ,is an approx. 300 kDa molecule, found predominantly in skin, blood vessels, liver, placenta, tongue, and thymus. Collagen type III forms cofibrils with type I and\/or V collagens in a number of tissues of mesenchymal origin, such as skin, tendon, ligaments, and bone. This collagen type is involved, directly or indirectly in several genetic diseases, including Ehlers-Danlos type IV disease.\u003cbr\u003e\nThis product was changed from ascites to tissue culture supernatant on 17 May 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.097% Sodium azideConstituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCollagen type III also known as COL3 and collagen III is a fibrillar protein with an approximate molecular mass of 138 kDa. This protein is a significant component of the extracellular matrix and is mainly expressed in connective tissues like skin lungs and vascular walls. You can also find it in developing tissues and fibrotic tissues reflecting its role during tissue growth and repair processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCollagen type III contributes to maintaining the structural integrity of tissues. It forms a complex with collagen type I providing a scaffold that ensures mechanical strength and stability to tissues. This structural pairing of collagen type I and III highlights their cooperative function in supporting the extracellular matrix and regulating cell behavior in tissue repair and wound healing processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nCollagen type III is integral to the processes of tissue repair and fibrosis pathways. It interacts closely with proteins such as fibronectin and integrins contributing to the cellular adhesion and signaling pathways important for fibroblast function and migration. These interactions reflect its essential role in matrix assembly and stability influencing how cells respond to injury and repair damaged tissues.\u003cbr\u003e\nCollagen type III mutations or dysregulation associate with vascular Ehlers-Danlos syndrome and keloids. In vascular Ehlers-Danlos syndrome defective collagen III compromises vessel wall integrity resulting in vascular fragility and rupture. In the context of keloids excessive collagen III accumulation in the skin illustrates its role in pathological fibrosis. Collagen type I is another protein that plays an important role in these conditions contributing along with collagen type III to the altered structural and functional properties observed in these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844221292713,"sku":"ab6310","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab6310","provider":"Iright","version":"1.0","type":"link"}