{"product_id":"abcam-ab64957","title":"Abcam, ab64957, Anti-Renin Receptor antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal Renin Receptor antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human ATP6AP2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ATP6AP2. The exact immunogen used to generate this antibody is proprietary information.O75787\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Renin Receptor also known as ATP6AP2 or the (pro)renin receptor is an important protein involved in the regulation of the renin-angiotensin system. It has a molecular mass of approximately 37 kDa. Expressed widely across several tissues including the kidneys heart and brain it acts by binding renin and prorenin leading to their activation and subsequent signaling. This receptor also facilitates cellular responses by increasing the efficiency of angiotensinogen conversion to angiotensin I which is a precursor to the potent vasoconstrictor angiotensin II.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe Renin Receptor participates in maintaining homeostasis within the renin-angiotensin-aldosterone system. It potentially forms part of a larger receptor complex by interacting with other pathway components. By modulating the activity of renin and prorenin it enhances blood pressure regulation and fluid balance contributing to cardiovascular function and cellular ion homeostasis. Its involvement extends to promoting cell signaling events related to growth development and metabolism through the MAPK pathway.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe Renin Receptor integrates into the renin-angiotensin system and the Wnt signaling pathway. In the renin-angiotensin system the receptor interacts with proteins such as angiotensin-converting enzyme (ACE) and angiotensin receptors playing an important role in blood pressure and electrolyte balance. Its engagement in the Wnt pathway suggests a role in development and cellular proliferation highlighting its interaction with proteins involved in cellular communication and embryonic development.\u003cbr\u003e\nThe Renin Receptor is linked to hypertension and cardiovascular diseases. Its overactivity or dysregulation may lead to elevated blood pressure due to increased angiotensin II formation. Additionally it is associated with heart failure where it contributes to pathological cardiac remodeling. The receptor's interaction with ACE and the renin-angiotensin system components highlights its involvement in these cardiovascular disorders suggesting potential targets for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850089746601,"sku":"ab64957","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab64957","provider":"Iright","version":"1.0","type":"link"}