{"product_id":"abcam-ab67681","title":"Abcam, ab67681, Anti-FGD5 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal FGD5 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FGD5.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human FGD5.Q6ZNL6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFGD5 also known as Faciogenital Dysplasia 5 is a protein that functions mechanically as a Rho GTPase exchange factor. It has an approximate mass of 145 kilodaltons. FGD5 features an FYVE finger domain which is essential for its binding to phosphatidylinositol 3-phosphate. It is expressed significantly in endothelial cells suggesting a role in vascular development. Additionally FGD5 can be found in various tissues throughout the body highlighting its potential diverse functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFGD5 contributes to cytoskeletal organization by activating the Rho family of GTPases which are important for cell shape and movement. The protein does not appear to be part of a larger protein complex but its interactions with the cytoskeleton suggest it plays an important role in endothelial cell function. These activities point to its involvement in angiogenesis and other vascular processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nFGD5 acts in the MAPK signaling pathway contributing to cellular responses triggered by external signals like growth factors. It is also linked to the VEGF pathway which is critical for blood vessel formation. Interactions with other proteins such as VEGFR2 and ERK1\/2 enable FGD5 to regulate endothelial cell proliferation and migration thereby influencing vascular remodeling.\u003cbr\u003e\nFGD5 has been implicated in cardiovascular diseases and cancer. Its role in blood vessel formation and maintenance associates it with pathological conditions where abnormal angiogenesis is a factor. FGD5 alterations can affect disease progression with possible links to the overexpression of proteins like VEGF and PDGF in cancer highlighting its importance in understanding these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852260888745,"sku":"ab67681","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab67681","provider":"Iright","version":"1.0","type":"link"}