{"product_id":"abcam-ab68611","title":"Abcam, ab68611, Anti-TTLL1 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nMouse Polyclonal TTLL1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TTLL1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human TTLL1.O95922\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTTLL1 also known as Tubulin Tyrosine Ligase Like 1 is an enzyme with a molecular weight of approximately 42 kDa. It adds polyglutamate chains to tubulin modifying microtubule function. TTLL1 predominantly resides in the brain though various other tissues also express it. This protein plays a mechanical role in maintaining proper microtubule dynamics by post-translational modification of tubulins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTTLL1 contributes to the stability and function of neuronal microtubules. It does not function as part of a complex but interacts directly with tubulin subunits. By modifying the microtubules TTLL1 affects cellular processes reliant on cytoskeletal function such as cell division intracellular transport and maintenance of cell shape. This modification often results in regulation and targeting of microtubules to specific cellular locations and functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nTTLL1 participates in cytoskeleton-associated processes influencing the regulation of microtubule-associated pathways. It relates closely to the tubulin code hypothesis which proposes that tubulin post-translational modifications tag microtubules for interaction with microtubule-associated proteins. TTLL1's actions show a relationship with proteins like kinesins and dyneins essential for intracellular transport mechanisms and also influence cell structural integrity through these pathways.\u003cbr\u003e\nTTLL1 has associations with neurodegenerative diseases worrying scientists in this field. Alterations in its function are linked to cerebellar ataxia a condition that affects movement coordination. Through such a disorder TTLL1 shows connections to other proteins like ataxin suggesting cooperative roles in neuronal stability and function. Researchers also study TTLL1 in the context of cancers as its dysregulation may lead to improper cell division and tumorigenesis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852262559913,"sku":"ab68611","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab68611","provider":"Iright","version":"1.0","type":"link"}