{"product_id":"abcam-ab69252","title":"Abcam, ab69252, FITC Anti-Borrelia burgdorferi antibody","description":"\u003cp\u003eSize: 500µL\u003cbr\u003e\nRabbit Polyclonal Borrelia burgdorferi antibody - conjugated to FITC. Suitable for ICC\/IF, IHC-P, WB and reacts with Borreliella burgdorferi samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing Borrelia burgdorferi protein.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nConjugation:FITC,\u003cbr\u003e\nExcitation\/Emission:Ex: 495nm, Em: 519nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Borreliella burgdorferi,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody antibody reacts with Borrelia burgdorferi in bacterial and infected tissue samples.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.1% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nBorrelia burgdorferi known also as B. burgdorferi is a bacterium responsible for Lyme disease. It is a spirochete a type of bacteria distinguished by its corkscrew shape. This bacterium has a mass of approximately 1.5 million daltons. B. burgdorferi expresses surface proteins that have important roles in its survival and transmission including OspA and OspC which are key in interacting with host immune systems. These surface proteins allow Borrelia burgdorferi to adapt to different environments within tick vectors and mammalian hosts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe surface proteins of B. burgdorferi enable the bacterium to evade host immune responses. These components do not form part of a larger protein complex but they interact directly with host tissues to facilitate infection. B. burgdorferi's ability to alter its surface proteins through genetic recombination is a major factor in its persistence in host organisms. Its expression strategies enable it to adapt as a pathogen inside both the tick vector and mammalian hosts such as humans where it establishes chronic infections.\u003cbr\u003e\nPathways\u003cbr\u003e\nSurface proteins like OspA and OspC play essential roles in the infection pathways used by Borrelia burgdorferi. Within the tick OspA enables adherence to tick midgut cells affecting transmission pathways when feeding. In mammals proteins like OspC assist the bacterium in evading the host's immune system contributing to pathways involving immune evasion and tissue infiltration. These protein interactions allow B. burgdorferi to exploit weaknesses in host defenses distinguishing this spirochete in bacterial pathogenesis.\u003cbr\u003e\nBorrelia burgdorferi is directly related to Lyme disease a condition that if untreated can lead to severe neurological and arthritic symptoms. The surface protein OspC is particularly significant in early-stage Lyme disease and is a primary target for research into disease markers. In chronic cases Borrelia antibodies may not be effective leading to persistent infection. Additionally the relationship with other proteins like those in the host's immune pathways e.g. complement proteins is a current focus in understanding how B. burgdorferi achieves sustained infection in humans.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854240305321,"sku":"ab69252","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab69252","provider":"Iright","version":"1.0","type":"link"}