{"product_id":"abcam-ab69497","title":"Abcam, ab69497, Anti-UNC93B1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal UNC93B1 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:ab69497 will not crossreact with Unc93A.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUNC93B1 also known as protein unc-93 homolog B1 is a transmembrane protein with a mass of approximately 63 kDa. It is expressed mainly in the endoplasmic reticulum of various cell types playing a significant role within these intracellular membranes. This protein serves as an important mediator in the transportation of Toll-like receptors (TLRs) from the endoplasmic reticulum to endosomes influencing the immune response.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUNC93B1 acts as a regulator of innate immunity by ensuring proper localization and functioning of TLRs which recognize pathogen-associated molecular patterns. UNC93B1 forms a complex with these receptors which are proteins critical for pathogen recognition and immune system activation. It facilitates TLR trafficking affecting the downstream signaling that triggers immune responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe signaling cascades activated by TLRs involve UNC93B1 as an essential component in the toll-like receptor pathway and the MyD88-dependent signaling pathway. By binding with TLRs UNC93B1 influences pathways that involve MyD88 and IRAK4 driving the production of pro-inflammatory cytokines. These interactions highlight its role in orchestrating cellular responses to infections.\u003cbr\u003e\nUNC93B1's malfunction can lead to immune system deficiencies including systemic lupus erythematosus and herpes simplex encephalitis. Its interactions with TLRs influence these conditions as improper TLR function can result in inadequate immune responses. The protein also connects to MyD88 which plays a role in the pathways implicated in these disorders emphasizing its importance in maintaining immune system balance.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854221463721,"sku":"ab69497","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab69497","provider":"Iright","version":"1.0","type":"link"}