{"product_id":"abcam-ab69565","title":"Abcam, ab69565, Anti-HIPK4 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal HIPK4 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human HIPK4.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human HIPK4. The exact immunogen used to generate this antibody is proprietary information.Q8NE63\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHIPK4 known as Homeodomain Interacting Protein Kinase 4 acts as a serine\/threonine-protein kinase. It weighs around 69 kDa. This protein primarily localizes in the nucleus and occasionally the cytoplasm across various tissues. HIPK4 participates in phosphorylation processes modifying the activity of multiple substrates. Researchers often study it for its potential interactions with different transcription factors and regulators.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein plays an important role in regulating cell growth and differentiation. HIPK4 does not function as part of a complex but acts independently to impact these cellular processes. It can influence the expression of genes involved in apoptosis and cell cycle regulation indicating its significant influence on cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearchers recognize HIPK4's involvement in the Wnt signaling and JNK pathways. The protein interacts with other kinases such as HIPK2 which also play roles in these pathways. These interactions suggest that HIPK4 might have diverse biological effects including those on development and cancer evolution.\u003cbr\u003e\nScientists have linked HIPK4 to cancer and neurodegenerative diseases. It interacts with proteins like p53 which are important in tumor suppression. HIPK4's alteration may contribute to the development of cancer by disturbing the balance of cell proliferation and death. Additionally its dysregulation could potentially connect to neuronal cell death implicating a role in neurodegenerative conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854223036585,"sku":"ab69565","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab69565","provider":"Iright","version":"1.0","type":"link"}