{"product_id":"abcam-ab69927","title":"Abcam, ab69927, Anti-IQ motif containing B1 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal IQ motif containing B1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IQCB1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human IQCB1.Q15051\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nIQ motif containing B1 also known as IQCB1 or NPHP5 is a protein that functions mechanically as a part of cellular pathways involving microtubule dynamics. This protein has an approximate mass of 69 kDa and is widely expressed in various tissues with higher levels noted in the retina and kidney. The function of IQCB1 is closely related to its role in intracellular transport and sensory cilia signaling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIQ motif containing B1 plays an important role in the ciliary transition zone which is an important component in cilia formation and function. This protein is part of a protein complex known as the nephronophthisis module where it collaborates with other proteins to maintain ciliary structural integrity. Defects or mutations in IQCB1 may disrupt this module highlighting its significance in normal cellular operations.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe IQ motif containing B1 is involved in the ciliogenesis and cilia function pathways. In these pathways it interacts with proteins such as NPHP6 (also known as CEP290) to regulate ciliary assembly and ensure proper signal transduction. IQCB1's function is essential for the proper maintenance of these pathways which are critical for sensory perception and cellular communication.\u003cbr\u003e\nMutations in IQ motif containing B1 are linked to conditions such as nephronophthisis and retinitis pigmentosa. The protein's interaction with other proteins like RPGR which is associated with retinitis pigmentosa emphasizes its role in multi-systemic diseases affecting the kidneys and eyes. Understanding the function and interaction of IQCB1 with these proteins provides insights into the mechanisms underlying these disorders and may guide future therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848591593641,"sku":"ab69927","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab69927","provider":"Iright","version":"1.0","type":"link"}