{"product_id":"abcam-ab70037","title":"Abcam, ab70037, Anti-IFRD1 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal IFRD1 antibody. Carrier free. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IFRD1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human IFRD1.O00458\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nInterferon-related developmental regulator 1 (IFRD1) also known as PC4 is involved in transcription regulation and cellular differentiation. It is a nuclear protein with a mass of approximately 48 kDa. IFRD1 is expressed in various tissue types including muscle lung and the immune system among others. As a transcriptional co-regulator it modulates the activity of several transcription factors through interactions with other proteins affecting gene expression patterns.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIFRD1 regulates immune response and cellular differentiation processes. It functions as part of the transcriptional regulation complex influencing genes involved in tissue regeneration and repair. In the immune system IFRD1 modulates macrophage activation and influences neutrophil survival. The involvement in these biological processes indicates its important role in both normal physiological functions and response to injury or inflammation.\u003cbr\u003e\nPathways\u003cbr\u003e\nIFRD1 significantly contributes to the NF-kB signaling and JAK\/STAT pathways. In these pathways it interacts with key regulatory proteins to influence transcriptional outcomes. The NF-kB pathway for instance involves interactions with transcription factors that control inflammation and immune responses. Meanwhile the JAK\/STAT pathway important for cytokine signaling sees IFRD1 engaging with STAT proteins. Through these pathways IFRD1 plays a role in regulating cellular responses to external stimuli.\u003cbr\u003e\nIFRD1 associates with cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). Research links IFRD1 with modulation of inflammation where improper regulation can exacerbate respiratory conditions as observed in CF. In COPD impaired IFRD1 function may lead to increased inflammation and deteriorated lung function. Relationships with other proteins such as the CFTR gene product in cystic fibrosis highlight IFRD1's potential role in the pathophysiology of these diseases offering insights into possible therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852264427689,"sku":"ab70037","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab70037","provider":"Iright","version":"1.0","type":"link"}