{"product_id":"abcam-ab70778","title":"Abcam, ab70778, Anti-DHX37 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal DHX37 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab70778 was affinity purified using an epitope specific to DHX37 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe DHX37 protein also known as DEAD-box helicase 37 functions mechanically as an ATP-dependent RNA helicase. It belongs to the DEAD-box family of proteins involved in altering RNA secondary structure. DHX37 has a molecular mass of approximately 124 kDa. One can detect its expression in the cytoplasm and nucleus across various tissues with high levels noted in the testes and brain indicating its importance in specific cellular activities.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDHX37 plays a pivotal role in ribosome biogenesis and RNA processing events. It participates in the assembly of pre-ribosomal particles a complex essential for maturing ribosomal RNA. This activity implies DHX37's involvement in the early stages of ribosome formation impacting protein synthesis broadly across eukaryotic cells. Its helicase activity is necessary for unwinding RNA duplexes facilitating the progression of these fundamental biological processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nDHX37 emerges as significant within the ribosome biogenesis pathway. This pathway chart important steps for the synthesis and assembly of ribosomes which are key for cellular translation machinery. Additionally DHX37 interacts with proteins like NOP56 and NOP58 in the same pathway highlighting its relational involvement and integral role in facilitating concerted actions among participating molecules.\u003cbr\u003e\nDHX37's dysfunction associates with intellectual disabilities and male infertility. Mutations in this protein can lead to compromised RNA processing and ribosome assembly affecting neural development and gametogenesis. It shows interactions with proteins such as X-linked mental retardation associated proteins which further ties its activity to cognitive impairment conditions. Understanding the molecular interplay of DHX37 in these contexts aids in the exploration of therapeutic avenues.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853977538729,"sku":"ab70778","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab70778","provider":"Iright","version":"1.0","type":"link"}