{"product_id":"abcam-ab70802","title":"Abcam, ab70802, Anti-ZC3H13 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal ZC3H13 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human ZC3H13.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ZC3H13. The exact immunogen used to generate this antibody is proprietary information.Q5T200\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle, Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZC3H13 also known as zinc finger CCCH-type containing 13 is a protein with mass around 110 kDa. This protein is recognized for its role in post-transcriptional regulation of gene expression by mediating methylation of the N6 position of adenosine residues within RNA molecules. It possesses zinc finger motifs which allow it to bind to RNA and participate in RNA processing. ZC3H13 is expressed in various tissues including the liver lungs and brain indicating its widespread influence in physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nZC3H13 functions as part of the m6A methyltransferase complex where it interacts with other proteins like METTL3 and METTL14. This complex modifies mRNA influencing its stability localization and translation efficiency. Through these actions ZC3H13 plays an important role in regulating RNA metabolism impacting numerous biological activities such as cellular differentiation and response to environmental stress.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe function of ZC3H13 integrates into both the mRNA processing and m6A methylation pathways. The protein maintains a strong link with RNA metabolism underpinning cellular processes critical for gene expression. In the pathways it associates with proteins like WTAP and KIAA1429 which coordinate to modulate mRNA methylation levels and stability therefore influencing gene expression patterns and cellular function.\u003cbr\u003e\nAbnormal function or expression of ZC3H13 is associated with cancer and developmental disorders such as acute myeloid leukemia. ZC3H13's activity is often altered in these conditions contributing to dysregulation of gene expression and uncontrolled cell growth. In cancer its connections with proteins like METTL3 play a role in oncogenic transformation highlighting its potential as a therapeutic target for intervention strategies aiming to modulate mRNA methylation and stabilize normal cellular functions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855813234857,"sku":"ab70802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab70802","provider":"Iright","version":"1.0","type":"link"}