{"product_id":"abcam-ab70810","title":"Abcam, ab70810, Anti-Rad9 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Rad9 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human RAD9A.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human RAD9A. The exact immunogen used to generate this antibody is proprietary information.Q99638\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRad9 also known as RAD9A is an important component in the cell cycle checkpoint control and DNA repair mechanisms. The Rad9 protein has a molecular weight of approximately 48 kDa. It functions as a part of the 9-1-1 complex a sensor of DNA damage during cell cycle progression. Rad9 is expressed mainly in the nucleus of cells where it participates in recognizing and binding to DNA at sites of damage. Through its interaction with other checkpoint proteins it facilitates the recruitment and activation of enzymes involved in DNA repair.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe Rad9 protein plays a central role in maintaining genomic stability. It acts as a DNA damage sensor and is part of the heterotrimeric 9-1-1 complex consisting of Rad9 Rad1 and Hus1. This complex helps signal the presence of DNA damage to halt the cell cycle allowing time for repair mechanisms to resolve issues. Rad9 helps prevent mutations that can lead to cell death or cancer development by ensuring effective DNA repair processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe Rad9 protein functions in the DNA damage response and cell cycle checkpoint pathways. As part of these pathways it interacts with proteins such as ATR and Chk1 which are responsible for transmitting signals that initiate cell cycle arrest and DNA repair. The 9-1-1 complex with Rad9 as a critical component links the detection of DNA lesions to the activation of downstream effector proteins facilitating an appropriate cellular response to DNA damage.\u003cbr\u003e\nRad9 has been linked to cancer and other conditions involving genomic instability. Alterations in Rad9 function can impair the DNA damage response leading to the accumulation of mutations that predispose cells to cancerous transformations. Furthermore the protein's relationship with BRCA1 a well-known tumor suppressor gene highlights its role in breast cancer susceptibility. Disruptions in the Rad9 associated pathways may also contribute to other disorders where DNA repair is compromised such as certain types of anemias and other syndromes characterized by genomic instability.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850092728489,"sku":"ab70810","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab70810","provider":"Iright","version":"1.0","type":"link"}