{"product_id":"abcam-ab72225","title":"Abcam, ab72225, Anti-USP20 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal USP20 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human USP20.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human USP20. The exact immunogen used to generate this antibody is proprietary information.Q9Y2K6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUSP20 also known as ubiquitin-specific peptidase 20 is an enzyme involved in removing ubiquitin molecules from proteins a process that regulates protein degradation and stabilization. The molecular mass of USP20 is approximately 97 kDa. USP20 is widely expressed in various tissues including brain heart and skeletal muscle indicating its versatile role in different cellular contexts. It deubiquitinates substrates impacting their protein stability and controlling their signal pathways.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRemoval of ubiquitin from protein substrates is an important function of USP20 which interacts with diverse protein complexes. USP20 modulates stability of multiple proteins by preventing their proteasomal degradation. It is involved in maintaining balance in cellular protein levels which affects cellular activities like cell cycle progression and response to stress. This activity can significantly influence the timing of protein turnover impacting how cells respond to changes.\u003cbr\u003e\nPathways\u003cbr\u003e\nDeubiquitinating activities of USP20 significantly influence stress response and cellular signaling. USP20 functions within the NF-κB signaling pathway a critical mediator of immune response where it interacts with proteins such as IκBα stabilizing them by removing ubiquitin moieties. This regulatory mechanism is essential for proper NF-κB activation and immune response. Additionally USP20 plays a role in endoplasmic reticulum stress pathways by modulating GRP78 levels highlighting its involvement in protein folding and stress handling.\u003cbr\u003e\nDysregulation of USP20 is linked to several health conditions like cancer and neurodegenerative diseases. In cancer USP20 influences tumor progression by interacting with the protein MCL-1 an important factor in cell survival therefore affecting apoptosis. In neurodegenerative diseases disruptions in USP20 function or expression can lead to imbalance of protein homeostasis contributing to protein aggregation a common hallmark in diseases like Alzheimer's. Studying USP20 and its interconnected pathways and proteins offers insights into potential therapeutic strategies for these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853949063337,"sku":"ab72225","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab72225","provider":"Iright","version":"1.0","type":"link"}