{"product_id":"abcam-ab72244","title":"Abcam, ab72244, Anti-USP38 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal USP38 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human USP38.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human USP38. The exact immunogen used to generate this antibody is proprietary information.Q8NB14\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUSP38 or Ubiquitin Specific Peptidase 38 is a deubiquitinating enzyme with a pivotal role in the regulation of protein degradation. It maintains cellular protein levels by removing ubiquitin from specific substrates thereby controlling their stability and function. USP38 has an estimated mass of approximately 111 kDa. Expression of USP38 occurs in various tissues with notable expression in the brain and immune system indicating its broad relevance to many physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUSP38 participates in intricate cellular processes by modulating the ubiquitin-proteasome system. This protein is not generally described as part of a large complex acting predominantly as an independent agent in deubiquitination. Its activity affects cell cycle progression and apoptosis by selectively regulating substrate proteins involved in these functions. Such biological roles highlight its importance in cellular health and proliferation.\u003cbr\u003e\nPathways\u003cbr\u003e\nUSP38 interacts with critical signaling pathways including the NF-kB and p53 pathways. Within the NF-kB pathway USP38 modulates immune and inflammatory responses through its deubiquitinase activity potentially affecting proteins like IkB or other signaling regulators. In the context of the p53 pathway USP38 may influence cell cycle regulation and apoptosis through interacting proteins such as MDM2 a ubiquitin ligase associated with p53 degradation.\u003cbr\u003e\nAberrant USP38 function has links to cancer and neurodegenerative diseases. In cancer it influences tumor progression possibly by interacting with p53 and MDM2 affecting cell regulation and apoptosis. In neurodegenerative diseases such as Alzheimer's altered ubiquitination processes involving USP38 may disturb protein degradation contributing to disease pathology. These associations highlight UNC38 as an important target for potential therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850160820393,"sku":"ab72244","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab72244","provider":"Iright","version":"1.0","type":"link"}