{"product_id":"abcam-ab72753","title":"Abcam, ab72753, Anti-KSR2 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal KSR2 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Kinase suppressor of Ras 2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human Kinase suppressor of Ras 2. The exact immunogen used to generate this antibody is proprietary information.Q6VAB6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab72753 was Affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe KSR2 protein also known as Kinase Suppressor of Ras 2 operates as a scaffold protein. It functions by assembling a protein complex that is important for signal transduction. KSR2 has a molecular weight of approximately 104 kDa. This protein is widely expressed in various tissues most notably in the brain and adipose tissue where it plays key roles in cellular communication and metabolic regulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nKinase Suppressor of Ras 2 participates in the scaffolding of protein complexes required for MEK\/ERK signaling. KSR2 contributes to the regulation of cellular energy homeostasis and metabolic processes. It also acts as a facilitator that enhances the signaling efficiency of the MAPK pathway allowing proper transduction of growth and developmental signals. Its role in the modulation of energy balance involves effects on both glucose and fatty acid metabolism.\u003cbr\u003e\nPathways\u003cbr\u003e\nKSR2 interacts notably with the MEK\/ERK and AMPK signaling pathways. KSR2 modulates the MAPK pathway facilitating the phosphorylation of ERK an essential step for transmitting signals from membrane receptors to the nucleus. In the AMPK pathway KSR2 interacts indirectly with AMPK-related proteins impacting energy balance and cellular stress responses. Through these pathways KSR2 links with key proteins like Raf MEK and LKB1 important for signal transduction and energy regulation.\u003cbr\u003e\nKSR2 plays a significant role in obesity and type 2 diabetes. Mutations in KSR2 can lead to severe obesity accompanied by insulin resistance indicating its importance in regulating metabolism and energy consumption. Through these disorders KSR2 links with proteins such as AMPK which influences energy homeostasis and insulin signaling. Addressing KSR2 dysfunction may have therapeutic potential for metabolic diseases highlighting its importance in health and disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854216843433,"sku":"ab72753","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab72753","provider":"Iright","version":"1.0","type":"link"}