{"product_id":"abcam-ab75008","title":"Abcam, ab75008, Anti-ClC-4 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal ClC-4 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CLCN4.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human CLCN4. The exact immunogen used to generate this antibody is proprietary information.P51793\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nClC-4 also known as chloride channel 4 represents a member of the chloride channel family. It functions as an anion transporter facilitating the movement of chloride ions across cellular membranes. ClC-4 is expressed in various tissues including the kidney brain and skeletal muscle. The protein has a molecular weight of around 91 kDa and is encoded by the CLCN4 gene. Through its transmembrane domain operations ClC-4 helps maintain ion homeostasis and cell volume regulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe functions of ClC-4 involve ion exchange activities important for cellular operations. It does not act alone but is part of a larger complex in particular cell types. In neuronal tissues ClC-4 contributes to the modulation of synaptic transmission and neuronal excitability. Its activity affects the electrochemical gradient across cell membranes essential for normal cellular signaling and metabolism.\u003cbr\u003e\nPathways\u003cbr\u003e\nClC-4 plays a role in regulating systemic chloride homeostasis and acid-base balance. It functions within pathways related to cell signaling and volume regulation. ClC-4 connects to pathways involving other chloride channels such as ClC-3 and ClC-5 which share complementary roles in ion transport and cellular function. This integration helps maintain the overall balance of ionic and pH levels within the body.\u003cbr\u003e\nMutations or dysfunctions in ClC-4 link to neurological conditions like X-linked mental retardation and epilepsy. Such diseases suggest that disruptions in chloride ion transport involve broader neural networking issues. ClC-4's involvement in these disorders intersects with proteins such as ClC-3 which also engages in maintaining neuronal chloride homeostasis. Understanding ClC-4 can provide insights into the pathophysiology of these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854037242025,"sku":"ab75008","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab75008","provider":"Iright","version":"1.0","type":"link"}