{"product_id":"abcam-ab75224","title":"Abcam, ab75224, Anti-ITGA7 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal ITGA7 antibody. Suitable for ELISA, WB, IHC-Fr, IHC-P and reacts with Human, African green monkey samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human ITGA7.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:African green monkey, Human,\u003cbr\u003e\nApplications:IHC-Fr, ELISA, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ITGA7. The exact immunogen used to generate this antibody is proprietary information.Q13683,\u003cbr\u003e\nSpecificity:ab75224 detects endogenous levels of a fragment of activated ITGA7 resulting from cleavage adjacent to Glu959.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab75224 affinity purified from rabbit antiserum by affinity chromatography usingan epitope specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nITGA7 also known as integrin alpha 7 is a transmembrane protein that plays an important role in cell adhesion and signaling. Weighing approximately 124 kDa ITGA7 is part of the integrin family of proteins functioning as a receptor that binds primarily to extracellular matrix proteins such as laminins. It is expressed largely in skeletal and cardiac muscle tissues but research shows its presence in other tissues like the nervous system.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nITGA7 interacts with the beta-1 integrin subunit to form a heterodimeric receptor. This combination mediates cell-matrix adhesion promoting cell migration differentiation and survival. ITGA7 is also involved in the stabilization of mature muscle cells and development of muscle fibers. By engaging with specific laminin isoforms ITGA7 influences tissue architecture and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearchers recognize that ITGA7 is important in signaling pathways like the PI3K\/Akt pathway which affects cell growth and survival. ITGA7 interacts with proteins like focal adhesion kinase (FAK) to transmit signals from the extracellular matrix to the inside of the cell. This communication helps regulate cellular responses and adaptability in dynamic environments.\u003cbr\u003e\nITGA7 has connections to muscular dystrophy and certain types of cancer. Mutations or altered expression of ITGA7 can lead to muscular dystrophy where muscle function becomes compromised. In cancer altered ITGA7 expression may affect tumor progression and metastasis with connections to proteins such as dystroglycan. Understanding these relationships is essential for developing targeted therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850069135529,"sku":"ab75224","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab75224","provider":"Iright","version":"1.0","type":"link"}