{"product_id":"abcam-ab76472","title":"Abcam, ab76472, Anti-S100A10 antibody [EPR3317]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal S100A10 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 16 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR3317,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This product is not suitable for use on brain-related samples (such as astrocytes, hippocampus, and cerebellum) due to its low expression level in those tissues.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nRat: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nS100A10 also known as p11 is a member of the S100 protein family. It has a molecular weight of about 11 kDa. This protein usually exists in the cytoplasm and nucleus of many cell types including epithelial cells and immune cells. S100A10 shows high expression in tissues like lungs kidneys and the intestinal tract. This protein functions mechanically as a calcium-binding protein even though it actually does not bind calcium directly promoting its interaction with other proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nS100A10 is involved in different cellular processes such as membrane trafficking and cellular signaling. It forms a complex with annexin A2 which is vital for the regulation of processes like endocytosis and exocytosis. This complex helps stabilize plasma membrane phospholipids promoting various transport and signaling mechanisms. S100A10 also plays a role in cellular adhesion and migration connecting with actin cytoskeleton.\u003cbr\u003e\nPathways\u003cbr\u003e\nS100A10 takes part in pathways linked to cellular migration and angiogenesis. It connects with pathways modulating actin dynamics commonly interacting with other proteins like annexin A2 and ARF6. Additionally S100A10 is linked to the plasminogen activation pathway where it facilitates the conversion of plasminogen to plasmin impacting tissue remodeling processes and endothelial cell function.\u003cbr\u003e\nS100A10 has been linked to conditions such as cancer and inflammatory diseases. It has an association with annexin A2 in many cancer types suggesting its role in promoting tumor growth and invasion. Additionally S100A10 appears to play a part in depression by influencing serotonin signaling. Changes in S100A10 levels can disrupt cellular environments suggesting its significant link to the pathophysiology of these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844130623657,"sku":"ab76472","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab76472","provider":"Iright","version":"1.0","type":"link"}