{"product_id":"abcam-ab76843","title":"Abcam, ab76843, Anti-AHI1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal AHI1 antibody. Suitable for WB, IHC-P, IHC-Fr and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Jouberin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-Fr, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human Jouberin. The exact immunogen used to generate this antibody is proprietary information.Q8N157\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe AHI1 protein also known as Abelson helper integration site 1 protein weighs approximately 110 kDa. This protein plays an important role in cellular processes by interacting with the cytoskeleton and is expressed in various tissues with significant levels in the brain. AHI1 localizes to the centrosomes and is critical for intracellular signaling dynamics affecting cellular shape and polarity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe AHI1 protein impacts several cellular functions. It acts as a scaffold protein that is part of large protein complexes. In particular AHI1 interacts with other proteins like NPHP1 important for positioning ciliary transition zones. These interactions are vital for maintaining normal cilia function which influences signal transduction related to both neuronal and renal functions in the body.\u003cbr\u003e\nPathways\u003cbr\u003e\nFunctions of AHI1 include involvement in the Shh (Sonic hedgehog) signaling pathway and JAK-STAT signaling. These pathways are key for cell growth differentiation and proliferation. AHI1's role in the Shh pathway connects it with proteins such as Gli proteins while its association with the JAK-STAT pathway involves complex interactions with various janus kinases.\u003cbr\u003e\nAHI1 mutations have strong associations with neurodevelopmental disorders such as Joubert syndrome and schizophrenia. In Joubert syndrome AHI1 interacts with CEP290 another protein involved in ciliary function leading to phenotypic manifestations when mutations disrupt this interaction. Similarly alterations in AHI1 can contribute to schizophrenia due to its role in neuronal signaling pathways and brain development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860526944425,"sku":"ab76843","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab76843","provider":"Iright","version":"1.0","type":"link"}