{"product_id":"abcam-ab7753","title":"Abcam, ab7753, Anti-pan Cytokeratin antibody [C-11]","description":"\u003cp\u003eSize: 20µg \/ 100µg \/ 1mg\u003cbr\u003e\nAnti-pan Cytokeratin antibody [C-11] (ab7753) is a mouse monoclonal antibody detecting pan Cytokeratin in  Flow Cytometry (Intra), Flow Cytometry, IHC-P, IHC-Fr, ICC\/IF, mIHC . Suitable for  Human, Mouse, Rat . - Multiplex IHC validated on the Leica BOND® MAX using Opal reagents - Over 140 publications - Trusted since 2001\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:C-11,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, mIHC, Flow Cyt (Intra), ICC\/IF, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Cytokeratin peptides 4,5,6,8,10,13,18.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product has switched from a hybridoma to recombinant production method on 08\u003cbr\u003e\nMarch 2021\u003cbr\u003e\nProduct Specifications\u003cbr\u003e\nAnti-pan Cytokeratin antibody [C-11] (ab7753) is a mouse recombinant monoclonal antibody and is validated for use in Flow Cyt (Intra), ICC\/IF, IHC-Fr, IHC-P, mIHC in human, mouse, rat samples.\u003cbr\u003e\nAnti-pan Cytokeratin antibody [C-11] (ab7753) specifically detects pan Cytokeratin (UniProt ID: Q7Z794; Molecular weight: 62kDa) and is sold in a convenient trial size to enable initial testing (20 µg) and larger sizes for subsequent scaling up experiments (100 µg and 1 mg).\u003cbr\u003e\nQuality and Validation\u003cbr\u003e\nAbcam's high quality manufacturing and validation processes ensure Anti-pan Cytokeratin antibody [C-11] (ab7753) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.\u003cbr\u003e\nAnti-pan Cytokeratin antibody [C-11] (ab7753) has been cited over 146 times in peer reviewed journals and is trusted by the scientific community.\u003cbr\u003e\nAnti-pan Cytokeratin antibody [C-11] (ab7753) has 23 independent reviews from customers.\u003cbr\u003e\nRelated Products\u003cbr\u003e\nAntibody clone C-11 is also available pre-conjugated to a variety of labels for your convenience - PE, APC, Alexa Fluor® 594, Alexa Fluor® 488, Alexa Fluor® 555, Alexa Fluor® 647 (\u003cbr\u003e\nab52460\u003cbr\u003e\nab106166\u003cbr\u003e\nab277234\u003cbr\u003e\nab277270\u003cbr\u003e\nab279324\u003cbr\u003e\nab309978\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Purified from TCS. Purity \u0026gt;95% by SDS-PAGE., Storage buffer-pH: 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPan cytokeratin also known as cytokeratin AE1\/AE3 is a cytoskeletal protein complex that consists of different keratin polypeptides. It mechanically supports epithelial cells contributing to their structural integrity. The protein mass is variable due to its composite nature ranging between 40 to 67 kDa. Pan cytokeratin is expressed in epithelial tissues throughout the body serving as a reliable marker for identifying epithelial origin cells in histological studies.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nKeratins in pan cytokeratin contribute to maintaining structural stability within epithelial cells. They act as components of the cytoskeletal network interacting with other cellular structures to provide protection from stress and mechanical damage. Pan cytokeratin exists as part of the intermediate filament protein complex which plays a significant role in cellular mechanics and cohesion essential for tissue integrity.\u003cbr\u003e\nPathways\u003cbr\u003e\nIntermediate filaments containing pan cytokeratin participate in pathways related to cell differentiation and stress response. Its interactions with other proteins like desmoplakin and plectin link the cytoskeletal filaments to cell membranes and the extracellular matrix. This involvement is important in pathways related to cellular structural integrity and epithelial-mesenchymal transition (EMT).\u003cbr\u003e\nPan cytokeratin serves as a critical marker in the diagnosis of epithelial-derived cancers such as carcinoma and conditions like psoriasis. Abnormal expression patterns of pan cytokeratin indicate tumor presence and origin. Its connection to proteins such as E-cadherin and vimentin assists in understanding the progression and metastasis of cancer by facilitating EMT and tissue invasion diagnostics.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844054470825,"sku":"ab7753","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab7753","provider":"Iright","version":"1.0","type":"link"}