{"product_id":"abcam-ab80157","title":"Abcam, ab80157, Recombinant Human M6PR (cation dependent) protein","description":"\u003cp\u003eSize: 1mg\u003cbr\u003e\nRecombinant Human M6PR (cation dependent) protein is a Human Fragment protein, in the 1 to 60 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:SDS-PAGE, WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P20645,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nReconstitution:Reconstitute in 1 mL of water,\u003cbr\u003e\nStorage buffer:Constituents: PBS\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nM6PR or mannose-6-phosphate receptor (cation dependent) is a protein involved in the transport of lysosomal enzymes from the Golgi apparatus to the lysosome. Alternate names for M6PR include CD-MPR and MPR46 reflecting its function and molecular weight of approximately 46 kDa. M6PR is expressed in various tissues but primarily found in the Golgi apparatus where it engages with lysosomal enzymes. This receptor is an important element in the delivery system that ensures lysosomal enzymes reach their intended cellular destination.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nM6PR acts as a sorting receptor by binding mannose-6-phosphate-tagged enzymes in the Golgi. It is involved in a complex trafficking mechanism that involves clathrin-coated vesicles. The receptor recognizes and binds to its ligands in the Golgi directing them to endosomes and eventually fusing with lysosomes. M6PR plays a critical role in maintaining lysosome functionality by regulating enzyme availability which is essential for cellular waste degradation and resource recycling.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe protein M6PR participates in the lysosomal enzyme targeting pathway that ensures proper enzyme sorting and delivery within cells. This pathway overlaps with the Golgi-to-endosome transport vesicle biogenesis involving proteins like clathrin and adaptin. M6PR interacts with proteins in the sorting pathway such as GGA adaptors and Hsc70 which assist in the recognition and transport processes necessary for lysosome integrity and function.\u003cbr\u003e\nThe malfunction of M6PR links to disorders like I-cell disease and mucolipidosis II characterized by defective lysosomal enzyme targeting. Impaired M6PR function can lead to the accumulation of undigested substrates within the lysosome causing cellular dysfunction. The receptor's failure can also indirectly affect protein interactions in diseases like mucolipidosis where relationships with proteins such as IGF2R can get altered further influencing cellular pathways and leading to various pathological conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843896823977,"sku":"ab80157","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab80157","provider":"Iright","version":"1.0","type":"link"}