{"product_id":"abcam-ab8399","title":"Abcam, ab8399, Anti-BNIP3L\/NIX antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal BNIP3L\/NIX antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 30 publications. Immunogen corresponding to Synthetic Peptide within Human BNIP3L aa 50-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nLight chain type:unknown,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human BNIP3L aa 50-100. The exact immunogen used to generate this antibody is proprietary information.O60238\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nMembers in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growingsubclass of the Bcl-2 family. A novel BH3 domaincontaining protein was recently identified and designated Bnip3L\/NIX, Bnip3a, and Nix (for Nip3-like protein X) (Matsushima, M. et al.; Yasuda, M. et al.; Chen, G, et al.).Bnip3L\/Bnip3a\/Nix is a homolog of the E1B 19K\/Bcl-2 binding and pro-apoptotic protein Bnip3. Over expression of Bnip3L\/NIX induces apoptosis (Yasuda, M. et al.; Chen, G, et al.). Bnip3L\/NIX interacts withand overcomes suppresses by Bcl-2 and Bcl-xL. Bnip3L\/NIX is localized in mitochondria. The messenger RNA of Bnip3L\/NIX is ubiquitously expressed in human tissues (Matsushima, M. et al.; Yasuda, M. et al.). Bnip3L\/NIX and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855814906025,"sku":"ab8399","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab8399","provider":"Iright","version":"1.0","type":"link"}